<i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation
Atopic dermatitis (AD) is a highly recurrent chronic inflammatory skin disease, characterized by severe itching, immune imbalance, and skin barrier dysfunction. Damage to the skin barrier function is known to be the main cause of Th1/Th2 immune imbalance, due to the Th2-mediated immune response, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1280 |
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| author | Eun-Nam Kim Hyun-Su Lee Gil-Saeng Jeong |
| author_facet | Eun-Nam Kim Hyun-Su Lee Gil-Saeng Jeong |
| author_sort | Eun-Nam Kim |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a highly recurrent chronic inflammatory skin disease, characterized by severe itching, immune imbalance, and skin barrier dysfunction. Damage to the skin barrier function is known to be the main cause of Th1/Th2 immune imbalance, due to the Th2-mediated immune response, and pro-inflammatory cytokines, including IL-4, IL-5, IL-13 and IL-31 and it plays an important role in further eliciting the environment of AD through stimulation. Currently, the most widely used drugs for the treatment of AD are corticosteroids, antihistamines and immunosuppressants (used by more than 60% of patients), which are reported to exhibit various side effects when taken for a long time. Therefore, interest in the physiological activity of safer plant-derived natural extracts is increasing. <i>Callicarpa dichotoma</i> is traditionally used in oriental medicine for bruises, habitual pain, gastric and postpartum hemorrhage. Recent studies have reported that it exhibits antioxidant anti-inflammatory and anti-hepatotoxic activity, but the role and activity of <i>C. dichotoma</i> in AD have not yet been studied. Therefore, in this study, the new physiological activity of <i>C. dichotoma</i> in the AD environment was investigated, suggesting its potential as a natural therapeutic agent. |
| first_indexed | 2024-03-09T19:36:15Z |
| format | Article |
| id | doaj.art-121ee41034c74b3894d536e6c2b3000e |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:15Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-121ee41034c74b3894d536e6c2b3000e2023-11-24T01:52:31ZengMDPI AGPharmaceuticals1424-82472022-10-011510128010.3390/ph15101280<i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes ActivationEun-Nam Kim0Hyun-Su Lee1Gil-Saeng Jeong2College of Pharmacy, Chungnam National University, Daejeon 34134, KoreaDepartment of Physiology, Daegu Catholic University School of Medicine, Daegu 42472, KoreaCollege of Pharmacy, Chungnam National University, Daejeon 34134, KoreaAtopic dermatitis (AD) is a highly recurrent chronic inflammatory skin disease, characterized by severe itching, immune imbalance, and skin barrier dysfunction. Damage to the skin barrier function is known to be the main cause of Th1/Th2 immune imbalance, due to the Th2-mediated immune response, and pro-inflammatory cytokines, including IL-4, IL-5, IL-13 and IL-31 and it plays an important role in further eliciting the environment of AD through stimulation. Currently, the most widely used drugs for the treatment of AD are corticosteroids, antihistamines and immunosuppressants (used by more than 60% of patients), which are reported to exhibit various side effects when taken for a long time. Therefore, interest in the physiological activity of safer plant-derived natural extracts is increasing. <i>Callicarpa dichotoma</i> is traditionally used in oriental medicine for bruises, habitual pain, gastric and postpartum hemorrhage. Recent studies have reported that it exhibits antioxidant anti-inflammatory and anti-hepatotoxic activity, but the role and activity of <i>C. dichotoma</i> in AD have not yet been studied. Therefore, in this study, the new physiological activity of <i>C. dichotoma</i> in the AD environment was investigated, suggesting its potential as a natural therapeutic agent.https://www.mdpi.com/1424-8247/15/10/1280atopic dermatitis<i>Callicarpa dichotoma</i>T cellskeratinocytesinterleukinthymic stromal lymphopoietin |
| spellingShingle | Eun-Nam Kim Hyun-Su Lee Gil-Saeng Jeong <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation Pharmaceuticals atopic dermatitis <i>Callicarpa dichotoma</i> T cells keratinocytes interleukin thymic stromal lymphopoietin |
| title | <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation |
| title_full | <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation |
| title_fullStr | <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation |
| title_full_unstemmed | <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation |
| title_short | <i>Callicarpa dichotoma</i> Leaf Extract Alleviates Atopic Dermatitis through the Suppression of T Cells and Keratinocytes Activation |
| title_sort | i callicarpa dichotoma i leaf extract alleviates atopic dermatitis through the suppression of t cells and keratinocytes activation |
| topic | atopic dermatitis <i>Callicarpa dichotoma</i> T cells keratinocytes interleukin thymic stromal lymphopoietin |
| url | https://www.mdpi.com/1424-8247/15/10/1280 |
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