Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin
Background: Adiponectin is secreted by adipose tissue and exerts high abundance and an anti-inflammatory potential. However, only little information exists about the expression profiles of adiponectin and its recently identified receptor CDH13 in non-tumorous human tissues and their association to c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-12-01
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| Series: | Obesity Facts |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/481732 |
| _version_ | 1818516978113970176 |
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| author | Simon Jasinski-Bergner Maximilian Büttner Dagmar Quandt Barbara Seliger Heike Kielstein |
| author_facet | Simon Jasinski-Bergner Maximilian Büttner Dagmar Quandt Barbara Seliger Heike Kielstein |
| author_sort | Simon Jasinski-Bergner |
| collection | DOAJ |
| description | Background: Adiponectin is secreted by adipose tissue and exerts high abundance and an anti-inflammatory potential. However, only little information exists about the expression profiles of adiponectin and its recently identified receptor CDH13 in non-tumorous human tissues and their association to clinical parameters. Methods: The expression levels of adiponectin and CDH13 were analyzed in heart, liver, kidney, spleen, skin, blood vessels, peripheral nerve and bone marrow of 21 human body donors, in 12 human cell lines, and in purified immune effector cell populations of healthy blood donors by immunohistochemistry, Western-blot, and semi-quantitative PCR. The obtained results were then correlated to clinical parameters, including age, sex and known diseases like cardiovascular and renal diseases. Results: Adiponectin expression in renal corpuscles was significantly higher in humans with known renal diseases. A coordinated expression of adiponectin and CDH13 was observed in the myocard. High levels of adiponectin could be detected in the bone marrow, in certain lymphoid tumor cell lines and in purified immune effector cell populations of healthy donors, in particular in cytotoxic T cells. Conclusion: For the first time, the expression profiles of adiponectin and CDH13 are analyzed in many human tissues in correlation to each other and to clinical parameters. |
| first_indexed | 2024-12-11T00:49:48Z |
| format | Article |
| id | doaj.art-121f19f0d1954d8e899acebd7baefe06 |
| institution | Directory Open Access Journal |
| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-11T00:49:48Z |
| publishDate | 2017-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-121f19f0d1954d8e899acebd7baefe062022-12-22T01:26:39ZengKarger PublishersObesity Facts1662-40251662-40332017-12-0110656958310.1159/000481732481732Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct OriginSimon Jasinski-BergnerMaximilian BüttnerDagmar QuandtBarbara SeligerHeike KielsteinBackground: Adiponectin is secreted by adipose tissue and exerts high abundance and an anti-inflammatory potential. However, only little information exists about the expression profiles of adiponectin and its recently identified receptor CDH13 in non-tumorous human tissues and their association to clinical parameters. Methods: The expression levels of adiponectin and CDH13 were analyzed in heart, liver, kidney, spleen, skin, blood vessels, peripheral nerve and bone marrow of 21 human body donors, in 12 human cell lines, and in purified immune effector cell populations of healthy blood donors by immunohistochemistry, Western-blot, and semi-quantitative PCR. The obtained results were then correlated to clinical parameters, including age, sex and known diseases like cardiovascular and renal diseases. Results: Adiponectin expression in renal corpuscles was significantly higher in humans with known renal diseases. A coordinated expression of adiponectin and CDH13 was observed in the myocard. High levels of adiponectin could be detected in the bone marrow, in certain lymphoid tumor cell lines and in purified immune effector cell populations of healthy donors, in particular in cytotoxic T cells. Conclusion: For the first time, the expression profiles of adiponectin and CDH13 are analyzed in many human tissues in correlation to each other and to clinical parameters.https://www.karger.com/Article/FullText/481732CDH13AdipoQT cadherinAdiponectinExpression |
| spellingShingle | Simon Jasinski-Bergner Maximilian Büttner Dagmar Quandt Barbara Seliger Heike Kielstein Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin Obesity Facts CDH13 AdipoQ T cadherin Adiponectin Expression |
| title | Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin |
| title_full | Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin |
| title_fullStr | Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin |
| title_full_unstemmed | Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin |
| title_short | Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin |
| title_sort | adiponectin and its receptors are differentially expressed in human tissues and cell lines of distinct origin |
| topic | CDH13 AdipoQ T cadherin Adiponectin Expression |
| url | https://www.karger.com/Article/FullText/481732 |
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