Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue
Introduction and purpose: free radicals cause more than 60 diseases; however, antioxidants can stop the harmful processes induced by free radicals in the body. In this regard, the present study aimed to investigate the effect of 8 weeks of strenuous endurance training (ET) and high-intensity interva...
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| Format: | Article |
| Language: | fas |
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Mazandaran University of Medical Sciences
2020-07-01
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| Series: | تحقیقات سلامت در جامعه |
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| Online Access: | http://jhc.mazums.ac.ir/article-1-480-en.html |
| _version_ | 1819174876178546688 |
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| author | Aghaali Ghasemnian Fariba Sojasi Gheydari Akram Karimiasl Hamidreza Norouzi |
| author_facet | Aghaali Ghasemnian Fariba Sojasi Gheydari Akram Karimiasl Hamidreza Norouzi |
| author_sort | Aghaali Ghasemnian |
| collection | DOAJ |
| description | Introduction and purpose: free radicals cause more than 60 diseases; however, antioxidants can stop the harmful processes induced by free radicals in the body. In this regard, the present study aimed to investigate the effect of 8 weeks of strenuous endurance training (ET) and high-intensity interval training (HT) on thioredoxin reductase-1 (TRX1) and malondialdehyde (MDA) in hippocampal tissue in male Wistar rats.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups of control, ET, and HT. The training protocols consisted of ET and HT on a treadmill for 8 weeks (5 days a week) and the hippocampal tissue samples were collected 48 h after the last session of training. Tissue concentration of TRX1 was measured by ELISA method and MDA concentration was measured by Thiobarbituric acid. Finally, the collected data were analyzed using the one-way analysis of variance.
Results: Based on the results, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups compared to the control group (P=0.62). Moreover, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups in comparison to the control group (P=0.83).
Conclusion: In conclusion, 8 weeks of ET and HT did not affect the TRX1 and TRX1 level in hippocampal tissue in male Wistar rats. |
| first_indexed | 2024-12-22T20:45:56Z |
| format | Article |
| id | doaj.art-121f9260c3284ab7a1da365e07a56a38 |
| institution | Directory Open Access Journal |
| issn | 2423-6772 2423-6764 |
| language | fas |
| last_indexed | 2024-12-22T20:45:56Z |
| publishDate | 2020-07-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | تحقیقات سلامت در جامعه |
| spelling | doaj.art-121f9260c3284ab7a1da365e07a56a382022-12-21T18:13:14ZfasMazandaran University of Medical Sciencesتحقیقات سلامت در جامعه2423-67722423-67642020-07-01628086Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal TissueAghaali Ghasemnian0Fariba Sojasi Gheydari1Akram Karimiasl2Hamidreza Norouzi3 Associate Professor, Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran MSc Student of Sport Physiology, Department of Sport Sciences, Faculty of Humanities, Zanjan University, Zanjan, Iran Assistant Professor, Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran Assistant Professor, Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran Introduction and purpose: free radicals cause more than 60 diseases; however, antioxidants can stop the harmful processes induced by free radicals in the body. In this regard, the present study aimed to investigate the effect of 8 weeks of strenuous endurance training (ET) and high-intensity interval training (HT) on thioredoxin reductase-1 (TRX1) and malondialdehyde (MDA) in hippocampal tissue in male Wistar rats. Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups of control, ET, and HT. The training protocols consisted of ET and HT on a treadmill for 8 weeks (5 days a week) and the hippocampal tissue samples were collected 48 h after the last session of training. Tissue concentration of TRX1 was measured by ELISA method and MDA concentration was measured by Thiobarbituric acid. Finally, the collected data were analyzed using the one-way analysis of variance. Results: Based on the results, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups compared to the control group (P=0.62). Moreover, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups in comparison to the control group (P=0.83). Conclusion: In conclusion, 8 weeks of ET and HT did not affect the TRX1 and TRX1 level in hippocampal tissue in male Wistar rats.http://jhc.mazums.ac.ir/article-1-480-en.htmlhippocampal tissuemalondialdehydestrenuous trainingthioredoxin reductase-1 |
| spellingShingle | Aghaali Ghasemnian Fariba Sojasi Gheydari Akram Karimiasl Hamidreza Norouzi Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue تحقیقات سلامت در جامعه hippocampal tissue malondialdehyde strenuous training thioredoxin reductase-1 |
| title | Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue |
| title_full | Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue |
| title_fullStr | Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue |
| title_full_unstemmed | Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue |
| title_short | Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue |
| title_sort | effects of strenuous endurance and high intensity interval training on thioredoxin reductase 1 enzyme and malondialdehyde in hippocampal tissue |
| topic | hippocampal tissue malondialdehyde strenuous training thioredoxin reductase-1 |
| url | http://jhc.mazums.ac.ir/article-1-480-en.html |
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