The role of resistin in the genesis of metabolic disorders in pathological pregnancy
Pathological gestational weight gain (GWG) is a risk factor for obstetric and perinatal complications. High metabolic activity of adipose tissue and the placenta during pregnancy manifests as an increased production of adipokines that are involved in glucose regulation and insulin sensitivity. The a...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2019-10-01
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| Series: | The Ukrainian Biochemical Journal |
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| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Ostafiichuk_5_19.pdf |
| _version_ | 1797422207522045952 |
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| author | S. O. Ostafiichuk |
| author_facet | S. O. Ostafiichuk |
| author_sort | S. O. Ostafiichuk |
| collection | DOAJ |
| description | Pathological gestational weight gain (GWG) is a risk factor for obstetric and perinatal complications. High metabolic activity of adipose tissue and the placenta during pregnancy manifests as an increased production of adipokines that are involved in glucose regulation and insulin sensitivity. The aim of this study was to determine the role of resistin in the genesis of metabolic disorders in pathological GWG pregnancies. The 163 pregnant women were examined in the study: 97 (59.5%) had normal, 18 (11.0%) had insufficient and 48 (29.4%) had excessive prepregnancy weight and obesity. GWG was the recommended level in 56 (34.4%), insufficient in 33 (20.2%), and excessive in 74 (45.4%) women. Anthropometry was performed in each trimester of pregnancy, the weight gain was measured, and the percentage of body fat mass, concentrations of resistin, glucose, insulin, and the HOMA-IR were evaluated. Positive associations were found between hyperresistinemia in the second trimester of pregnancy, and subsequent weight gain (r = 0.27, P = 0.0006), percentage of body fat mass (r = 0.93, P = 0.000) and insulin resistance (r = 0.89, P = 0.000) in late pregnancy; these associations were especially evident in excessive GWG. Determination of predictors of insulin resistance, associated with endocrine activity of adipose tissue, such as the adipokine resistin, in the second trimester of pregnancy may help to predict the severity of metabolic shifts during pregnancy and the risk of developing obstetric and perinatal complications. |
| first_indexed | 2024-03-09T07:29:52Z |
| format | Article |
| id | doaj.art-121fd40d627b4b8dac9ab2dca7785e28 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T07:29:52Z |
| publishDate | 2019-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-121fd40d627b4b8dac9ab2dca7785e282023-12-03T06:27:18ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032019-10-01915556210.15407/ubj91.05.055The role of resistin in the genesis of metabolic disorders in pathological pregnancyS. O. Ostafiichuk0Ivano-Frankivsk National Medical University, UkrainePathological gestational weight gain (GWG) is a risk factor for obstetric and perinatal complications. High metabolic activity of adipose tissue and the placenta during pregnancy manifests as an increased production of adipokines that are involved in glucose regulation and insulin sensitivity. The aim of this study was to determine the role of resistin in the genesis of metabolic disorders in pathological GWG pregnancies. The 163 pregnant women were examined in the study: 97 (59.5%) had normal, 18 (11.0%) had insufficient and 48 (29.4%) had excessive prepregnancy weight and obesity. GWG was the recommended level in 56 (34.4%), insufficient in 33 (20.2%), and excessive in 74 (45.4%) women. Anthropometry was performed in each trimester of pregnancy, the weight gain was measured, and the percentage of body fat mass, concentrations of resistin, glucose, insulin, and the HOMA-IR were evaluated. Positive associations were found between hyperresistinemia in the second trimester of pregnancy, and subsequent weight gain (r = 0.27, P = 0.0006), percentage of body fat mass (r = 0.93, P = 0.000) and insulin resistance (r = 0.89, P = 0.000) in late pregnancy; these associations were especially evident in excessive GWG. Determination of predictors of insulin resistance, associated with endocrine activity of adipose tissue, such as the adipokine resistin, in the second trimester of pregnancy may help to predict the severity of metabolic shifts during pregnancy and the risk of developing obstetric and perinatal complications.http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Ostafiichuk_5_19.pdfgestational weight gainglucoseinsulin resistanceresistin |
| spellingShingle | S. O. Ostafiichuk The role of resistin in the genesis of metabolic disorders in pathological pregnancy The Ukrainian Biochemical Journal gestational weight gain glucose insulin resistance resistin |
| title | The role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| title_full | The role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| title_fullStr | The role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| title_full_unstemmed | The role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| title_short | The role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| title_sort | role of resistin in the genesis of metabolic disorders in pathological pregnancy |
| topic | gestational weight gain glucose insulin resistance resistin |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Ostafiichuk_5_19.pdf |
| work_keys_str_mv | AT soostafiichuk theroleofresistininthegenesisofmetabolicdisordersinpathologicalpregnancy AT soostafiichuk roleofresistininthegenesisofmetabolicdisordersinpathologicalpregnancy |