53BP1 regulates heterochromatin through liquid phase separation

53BP1 regulates heterochromatin through liquid phase separation

The 53BP1 protein is well-known for its involvement in double-strand break (DSB) repair. Here the authors show 53BP1 undergoes significant liquid-liquid phase separation (LLPS) to play a role in heterochromatin maintenance and identify distinct domains/residues that function in DSB repair versus LLP...

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Bibliographic Details
Main Authors: Lei Zhang, Xinran Geng, Fangfang Wang, Jinshan Tang, Yu Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28019-y

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