Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

Due to its role in lipid biosynthesis, choline kinase α1 (CKα1) is an interesting target for the development of new antitumor agents. In this work, we present a series of 41 compounds designed based on the well-known and successful strategy of introducing thienopyridine and pyrimidine as bioisostere...

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Bibliographic Details
Main Authors: Pilar María Luque-Navarro, Elena Mariotto, Marco Ballarotto, Gianluca Rubbini, Francisco José Aguilar-Troyano, Alberto Fasiolo, Archimede Torretta, Emilio Parisini, Antonio Macchiarulo, Alejandro Laso, Carmen Marco, Giampietro Viola, María Paz Carrasco-Jimenez, Luisa Carlota López-Cara
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
antitumoral drug
choline kinase inhibition
choline uptake
Online Access:https://www.mdpi.com/1999-4923/14/4/715

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