Metabolism of copper and possibilities for its regulation
Copper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic. For this reason, cellular copper metabolism is tightly regulated and specific protein...
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| Format: | Article |
| Language: | English |
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Estonian Academy Publishers
2023-11-01
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| Series: | Proceedings of the Estonian Academy of Sciences |
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| Online Access: | https://kirj.ee/wp-content/plugins/kirj/pub/proc-4-2023-382-392_20231102003250.pdf |
| _version_ | 1797620581268455424 |
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| author | Peep Palumaa |
| author_facet | Peep Palumaa |
| author_sort | Peep Palumaa |
| collection | DOAJ |
| description | Copper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic. For this reason, cellular copper metabolism is tightly regulated and specific proteins â copper chaperones â participate in the metalation of cellular copper transporters and enzymes. The thermodynamic background for cellular copper distribution is known, and copper is driven to cellular destinations according to shallow affinity gradients. Copper metabolism is disturbed in the case of Wilsonâs, Menkes, and Alzheimerâs disease (AD), characterized by copper overload, deficiency, and misdistribution, respectively. Wilsonâs and Menkes disease could be treated by copper chelators and supplements, respectively; however, with AD, a search for effective molecular tools for the correction of copper metabolism is ongoing. One natural copperÂbinding ligand â αÂ-lipoic acid â has shown positive results in cellular and fruit fly models of AD and serves as a promising candidate for the regulation of copper metabolism in the case of AD. |
| first_indexed | 2024-03-11T08:44:38Z |
| format | Article |
| id | doaj.art-1220b86ace9447498ffe3cafe5d28c1f |
| institution | Directory Open Access Journal |
| issn | 1736-6046 1736-7530 |
| language | English |
| last_indexed | 2024-03-11T08:44:38Z |
| publishDate | 2023-11-01 |
| publisher | Estonian Academy Publishers |
| record_format | Article |
| series | Proceedings of the Estonian Academy of Sciences |
| spelling | doaj.art-1220b86ace9447498ffe3cafe5d28c1f2023-11-16T20:55:05ZengEstonian Academy PublishersProceedings of the Estonian Academy of Sciences1736-60461736-75302023-11-01724382392https://doi.org/10.3176/proc.2023.4.03https://doi.org/10.3176/proc.2023.4.03Metabolism of copper and possibilities for its regulationPeep Palumaa0Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, EstoniaCopper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic. For this reason, cellular copper metabolism is tightly regulated and specific proteins â copper chaperones â participate in the metalation of cellular copper transporters and enzymes. The thermodynamic background for cellular copper distribution is known, and copper is driven to cellular destinations according to shallow affinity gradients. Copper metabolism is disturbed in the case of Wilsonâs, Menkes, and Alzheimerâs disease (AD), characterized by copper overload, deficiency, and misdistribution, respectively. Wilsonâs and Menkes disease could be treated by copper chelators and supplements, respectively; however, with AD, a search for effective molecular tools for the correction of copper metabolism is ongoing. One natural copperÂbinding ligand â αÂ-lipoic acid â has shown positive results in cellular and fruit fly models of AD and serves as a promising candidate for the regulation of copper metabolism in the case of AD.https://kirj.ee/wp-content/plugins/kirj/pub/proc-4-2023-382-392_20231102003250.pdfcopper metabolismwilson’s diseasemenkes diseasealzheimer’s diseasecopper chelationcopper ionophoreslipoid acid |
| spellingShingle | Peep Palumaa Metabolism of copper and possibilities for its regulation Proceedings of the Estonian Academy of Sciences copper metabolism wilson’s disease menkes disease alzheimer’s disease copper chelation copper ionophores lipoid acid |
| title | Metabolism of copper and possibilities for its regulation |
| title_full | Metabolism of copper and possibilities for its regulation |
| title_fullStr | Metabolism of copper and possibilities for its regulation |
| title_full_unstemmed | Metabolism of copper and possibilities for its regulation |
| title_short | Metabolism of copper and possibilities for its regulation |
| title_sort | metabolism of copper and possibilities for its regulation |
| topic | copper metabolism wilson’s disease menkes disease alzheimer’s disease copper chelation copper ionophores lipoid acid |
| url | https://kirj.ee/wp-content/plugins/kirj/pub/proc-4-2023-382-392_20231102003250.pdf |
| work_keys_str_mv | AT peeppalumaa metabolismofcopperandpossibilitiesforitsregulation |