Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming

Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming

Background: Methicillin-resistant Staphylococcus aureus (MRSA) has now become a major nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of novel approaches to combat the disease is especially important. The present study aimed to provide a novel approach involvin...

Full description

Bibliographic Details
Main Authors: Lvyuan Fan, Zhiyu Pan, Xu Liao, Yilin Zhong, Juan Guo, Rui Pang, Xinhai Chen, Guozhu Ye, Yubin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
methicillin-resistant Staphylococcus aureus
uracil
gentamicin
TCA cycle
ROS
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1133685/full

Similar Items

Similar Items