Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study
This study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson’s disease (PD) and control subjects, and then explore the relationship between brain connectivity and the clinical features o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/14/7240 |
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| author | Fabiana Novellino Maria Salsone Roberta Riccelli Carmelina Chiriaco Giuseppe Argirò Andrea Quattrone José L. M. Madrigal Luigi Ferini Strambi Aldo Quattrone |
| author_facet | Fabiana Novellino Maria Salsone Roberta Riccelli Carmelina Chiriaco Giuseppe Argirò Andrea Quattrone José L. M. Madrigal Luigi Ferini Strambi Aldo Quattrone |
| author_sort | Fabiana Novellino |
| collection | DOAJ |
| description | This study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson’s disease (PD) and control subjects, and then explore the relationship between brain connectivity and the clinical features of our patients. Forty subjects (13 VP, 15 PD, and 12 age-and-sex-matched healthy controls) were enrolled in this study. They each underwent a careful clinical and neuropsychological evaluation, DAT-SPECT scintigraphy and 3T MRI scan. While there were no differences between PD and VP in the disease duration and severity, nor in terms of the DAT-SPECT evaluations, VP patients had a reduction in structural covariance between the bilateral corpus striatum (both putamen and caudate) and several brain regions, including the insula, thalamus, hippocampus, anterior cingulate cortex and orbito-frontal cortex compared to PD and controls. VP patients also showed lower scores on several neuropsychological tests. Interestingly, in the VP group, structural connectivity alterations were significantly related to cognitive evaluations exploring executive functions, memory, anxiety and depression. This compelling evidence suggests that structural disconnection in the basal ganglia circuits spreading in critical cortical regions may be involved in the pathophysiology of cognitive impairment in VP. |
| first_indexed | 2024-03-09T10:22:53Z |
| format | Article |
| id | doaj.art-12249618dbf34f9ba45481c4b4686c33 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T10:22:53Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-12249618dbf34f9ba45481c4b4686c332023-12-01T21:52:13ZengMDPI AGApplied Sciences2076-34172022-07-011214724010.3390/app12147240Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance StudyFabiana Novellino0Maria Salsone1Roberta Riccelli2Carmelina Chiriaco3Giuseppe Argirò4Andrea Quattrone5José L. M. Madrigal6Luigi Ferini Strambi7Aldo Quattrone8Institute of Molecular Bioimaging and Physiology, National Research Council, 88100 Catanzaro, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, 20054 Milano, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, 88100 Catanzaro, ItalyInstitute of Neurology, University “Magna Graecia”, 88100 Catanzaro, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, 88100 Catanzaro, ItalyInstitute of Neurology, University “Magna Graecia”, 88100 Catanzaro, ItalyDepartment of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Hospital 12 de Octubre (Imas12), Instituto de Investigación Neuroquímica (IUINQ-UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Complutense s/n, 28040 Madrid, SpainSleep Disorders Center, Division of Neuroscience, San Raffaele Scientific Institute, 20127 Milano, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, 88100 Catanzaro, ItalyThis study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson’s disease (PD) and control subjects, and then explore the relationship between brain connectivity and the clinical features of our patients. Forty subjects (13 VP, 15 PD, and 12 age-and-sex-matched healthy controls) were enrolled in this study. They each underwent a careful clinical and neuropsychological evaluation, DAT-SPECT scintigraphy and 3T MRI scan. While there were no differences between PD and VP in the disease duration and severity, nor in terms of the DAT-SPECT evaluations, VP patients had a reduction in structural covariance between the bilateral corpus striatum (both putamen and caudate) and several brain regions, including the insula, thalamus, hippocampus, anterior cingulate cortex and orbito-frontal cortex compared to PD and controls. VP patients also showed lower scores on several neuropsychological tests. Interestingly, in the VP group, structural connectivity alterations were significantly related to cognitive evaluations exploring executive functions, memory, anxiety and depression. This compelling evidence suggests that structural disconnection in the basal ganglia circuits spreading in critical cortical regions may be involved in the pathophysiology of cognitive impairment in VP.https://www.mdpi.com/2076-3417/12/14/7240Parkinson’s diseasevascular parkinsonismMRIstructural covariancecognitive impairment |
| spellingShingle | Fabiana Novellino Maria Salsone Roberta Riccelli Carmelina Chiriaco Giuseppe Argirò Andrea Quattrone José L. M. Madrigal Luigi Ferini Strambi Aldo Quattrone Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study Applied Sciences Parkinson’s disease vascular parkinsonism MRI structural covariance cognitive impairment |
| title | Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study |
| title_full | Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study |
| title_fullStr | Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study |
| title_full_unstemmed | Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study |
| title_short | Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study |
| title_sort | connectivity alterations in vascular parkinsonism a structural covariance study |
| topic | Parkinson’s disease vascular parkinsonism MRI structural covariance cognitive impairment |
| url | https://www.mdpi.com/2076-3417/12/14/7240 |
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