Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis
Lusine Hazarapetyan,1,2 Parounak H Zelveian,2 Svetlana Grigoryan1,2 1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia; 2Scientific Research Institute of Cardiology Named After L Hovhannisyan, Yerevan, ArmeniaCorrespondence: Svetlana Grigoryan, Depar...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/inflammation-and-coagulation-are-two-interconnected-pathophysiological-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797643714941681664 |
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| author | Hazarapetyan L Zelveian PH Grigoryan S |
| author_facet | Hazarapetyan L Zelveian PH Grigoryan S |
| author_sort | Hazarapetyan L |
| collection | DOAJ |
| description | Lusine Hazarapetyan,1,2 Parounak H Zelveian,2 Svetlana Grigoryan1,2 1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia; 2Scientific Research Institute of Cardiology Named After L Hovhannisyan, Yerevan, ArmeniaCorrespondence: Svetlana Grigoryan, Department of Cardiology, Yerevan State Medical University, 5 P. Sevak Street, Yerevan, 0044, Armenia, Tel +374-91-415 − 123, Email s.grigoryan@interdiagnostika.comIntroduction: Atrial fibrillation (AF) is associated with elevated levels of clotting factors such as tissue factor (TF) and factor XII (FXII). Various inflammation markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), and high-sensitive C-reactive protein (hs-CRP), have also been associated with AF. This study explores the relationship between inflammation markers and coagulation activity, including their impact on heart structural changes in these patients.Methods: We observed 283 patients with nonvalvular AF who underwent a complete examination at admission, but only 183 patients have successful cardioversion. As a control group, similar patients without AF were examined. The markers of the coagulation and inflammation were studied by ELISA on the analyzer “Stat Fax 303 Plus”. Studies were conducted using l statistical package SPSS 13.0.Results: It was revealed that patients with AF had significantly higher levels of hs-CRP, IL-6, and TNF-α and had elevated levels of TF and FXII compared with control group. The moderate correlations were observed between IL-6 and left atrial diameter (LAD), IL-6 and LA stiffness, hs-CRP and left atrial volume (LAV), TF and LAV.Conclusion: We have demonstrated that patients with AF have the relationship between elevated levels of inflammatory markers and coagulation activity, which contributes to structural atrial remodeling.Keywords: atrial fibrillation, hs-C reactive protein, interleukin-6, tissue factor, factor XII |
| first_indexed | 2024-03-11T14:19:57Z |
| format | Article |
| id | doaj.art-12282e2fc6ca4000bcc57391018d48c2 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-11T14:19:57Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-12282e2fc6ca4000bcc57391018d48c22023-10-31T17:33:54ZengDove Medical PressJournal of Inflammation Research1178-70312023-10-01Volume 164967497587748Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation PathogenesisHazarapetyan LZelveian PHGrigoryan SLusine Hazarapetyan,1,2 Parounak H Zelveian,2 Svetlana Grigoryan1,2 1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia; 2Scientific Research Institute of Cardiology Named After L Hovhannisyan, Yerevan, ArmeniaCorrespondence: Svetlana Grigoryan, Department of Cardiology, Yerevan State Medical University, 5 P. Sevak Street, Yerevan, 0044, Armenia, Tel +374-91-415 − 123, Email s.grigoryan@interdiagnostika.comIntroduction: Atrial fibrillation (AF) is associated with elevated levels of clotting factors such as tissue factor (TF) and factor XII (FXII). Various inflammation markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), and high-sensitive C-reactive protein (hs-CRP), have also been associated with AF. This study explores the relationship between inflammation markers and coagulation activity, including their impact on heart structural changes in these patients.Methods: We observed 283 patients with nonvalvular AF who underwent a complete examination at admission, but only 183 patients have successful cardioversion. As a control group, similar patients without AF were examined. The markers of the coagulation and inflammation were studied by ELISA on the analyzer “Stat Fax 303 Plus”. Studies were conducted using l statistical package SPSS 13.0.Results: It was revealed that patients with AF had significantly higher levels of hs-CRP, IL-6, and TNF-α and had elevated levels of TF and FXII compared with control group. The moderate correlations were observed between IL-6 and left atrial diameter (LAD), IL-6 and LA stiffness, hs-CRP and left atrial volume (LAV), TF and LAV.Conclusion: We have demonstrated that patients with AF have the relationship between elevated levels of inflammatory markers and coagulation activity, which contributes to structural atrial remodeling.Keywords: atrial fibrillation, hs-C reactive protein, interleukin-6, tissue factor, factor XIIhttps://www.dovepress.com/inflammation-and-coagulation-are-two-interconnected-pathophysiological-peer-reviewed-fulltext-article-JIRatrial fibrillationhs- c reactive proteininterleukine-6tissue factorfactor xii |
| spellingShingle | Hazarapetyan L Zelveian PH Grigoryan S Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis Journal of Inflammation Research atrial fibrillation hs- c reactive protein interleukine-6 tissue factor factor xii |
| title | Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis |
| title_full | Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis |
| title_fullStr | Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis |
| title_full_unstemmed | Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis |
| title_short | Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis |
| title_sort | inflammation and coagulation are two interconnected pathophysiological pathways in atrial fibrillation pathogenesis |
| topic | atrial fibrillation hs- c reactive protein interleukine-6 tissue factor factor xii |
| url | https://www.dovepress.com/inflammation-and-coagulation-are-two-interconnected-pathophysiological-peer-reviewed-fulltext-article-JIR |
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