Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children
Abstract Background To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13620 |
| _version_ | 1797773520904650752 |
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| author | Fei Fan Jun Lv Qianyuan Yang Fei Jiang |
| author_facet | Fei Fan Jun Lv Qianyuan Yang Fei Jiang |
| author_sort | Fei Fan |
| collection | DOAJ |
| description | Abstract Background To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease. Methods The study included 265 children with MPP and 230 children with NMPP in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from 2020 to 2021. The children with MPP included RMPP (n = 85) and GMPP (n = 180). Demographic and clinical characteristics, laboratory and imaging findings of all children were measured as baseline data within 24 h after admission and the differences between MPP and NMPP, RMPP and GMPP patients were compared. ROC curves were used to evaluate the diagnostic and predictive value of different indicators for RMPP. Results Fever duration and hospital stay in children with MPP were longer than those with NMPP. The number of patients with imaging features of pleural effusion, lung consolidation and bronchopneumonia in MPP group was significantly higher than that in NMPP group. Compared with NMPP group, the levels of C‐reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), lactic dehydrogenase (LDH), prothrombin time (PT), fibrinogen (FIB) and D‐dimer and inflammatory cytokines (interleukin [IL]‐6, IL‐8, IL‐10 and IL‐1β) in MPP group were significantly higher (P < 0.05). The clinical symptoms and pulmonary imaging findings were more severe in RMPP group. The levels of white blood cell (WBC), CRP, PCT, SAA, ESR, alanine aminotransferase (ALT), LDH, ferritin, PT, FIB, D‐dimer and inflammatory cytokines in RMPP group were higher than those in GMPP group. There was no significant difference in the level of lymphocyte subsets between the RMPP and GMPP group. IL‐6, IL‐10, LDH, PT, D‐dimer and lung consolidation were independent risk factors for RMPP. IL‐6 levels and LDH activity were good predictors of RMPP. Conclusion In conclusion, there were differences in clinical characteristics and serum inflammatory markers between MPP group and NMPP group, RMPP group and GMPP group. IL‐6, IL‐10, LDH, PT and D‐dimer can be used as predictive indicators for RMPP. |
| first_indexed | 2024-03-12T22:07:41Z |
| format | Article |
| id | doaj.art-122beb9d620c4bc5b9881c523d835a2f |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-03-12T22:07:41Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-122beb9d620c4bc5b9881c523d835a2f2023-07-24T07:49:02ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-07-0117760761710.1111/crj.13620Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in childrenFei Fan0Jun Lv1Qianyuan Yang2Fei Jiang3Department of Paediatrics The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Paediatrics The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Paediatrics The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu ChinaDepartment of Paediatrics The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu ChinaAbstract Background To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease. Methods The study included 265 children with MPP and 230 children with NMPP in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from 2020 to 2021. The children with MPP included RMPP (n = 85) and GMPP (n = 180). Demographic and clinical characteristics, laboratory and imaging findings of all children were measured as baseline data within 24 h after admission and the differences between MPP and NMPP, RMPP and GMPP patients were compared. ROC curves were used to evaluate the diagnostic and predictive value of different indicators for RMPP. Results Fever duration and hospital stay in children with MPP were longer than those with NMPP. The number of patients with imaging features of pleural effusion, lung consolidation and bronchopneumonia in MPP group was significantly higher than that in NMPP group. Compared with NMPP group, the levels of C‐reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), lactic dehydrogenase (LDH), prothrombin time (PT), fibrinogen (FIB) and D‐dimer and inflammatory cytokines (interleukin [IL]‐6, IL‐8, IL‐10 and IL‐1β) in MPP group were significantly higher (P < 0.05). The clinical symptoms and pulmonary imaging findings were more severe in RMPP group. The levels of white blood cell (WBC), CRP, PCT, SAA, ESR, alanine aminotransferase (ALT), LDH, ferritin, PT, FIB, D‐dimer and inflammatory cytokines in RMPP group were higher than those in GMPP group. There was no significant difference in the level of lymphocyte subsets between the RMPP and GMPP group. IL‐6, IL‐10, LDH, PT, D‐dimer and lung consolidation were independent risk factors for RMPP. IL‐6 levels and LDH activity were good predictors of RMPP. Conclusion In conclusion, there were differences in clinical characteristics and serum inflammatory markers between MPP group and NMPP group, RMPP group and GMPP group. IL‐6, IL‐10, LDH, PT and D‐dimer can be used as predictive indicators for RMPP.https://doi.org/10.1111/crj.13620cytokinelymphocyte subsetsMycoplasma pneumoniae pneumonianon‐mycoplasma pneumoniae pneumoniarefractory mycoplasma pneumoniae pneumonia |
| spellingShingle | Fei Fan Jun Lv Qianyuan Yang Fei Jiang Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children The Clinical Respiratory Journal cytokine lymphocyte subsets Mycoplasma pneumoniae pneumonia non‐mycoplasma pneumoniae pneumonia refractory mycoplasma pneumoniae pneumonia |
| title | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
| title_full | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
| title_fullStr | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
| title_full_unstemmed | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
| title_short | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
| title_sort | clinical characteristics and serum inflammatory markers of community acquired mycoplasma pneumonia in children |
| topic | cytokine lymphocyte subsets Mycoplasma pneumoniae pneumonia non‐mycoplasma pneumoniae pneumonia refractory mycoplasma pneumoniae pneumonia |
| url | https://doi.org/10.1111/crj.13620 |
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