Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies

Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies

Summary: Background: Reduced glucocorticoid-receptor (GR) expression in blood suggested that critically ill patients become glucocorticoid-resistant necessitating stress-doses of glucocorticoids. We hypothesised that critical illness evokes a tissue-specific, time-dependent expression of regulators...

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Main Authors: Arno Téblick, Lisa Van Dyck, Nathalie Van Aerde, Sarah Van der Perre, Lies Pauwels, Inge Derese, Yves Debaveye, Pieter J. Wouters, Ilse Vanhorebeek, Lies Langouche, Greet Van den Berghe
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:EBioMedicine
Subjects:
Glucocorticoid receptor
CIRCI
Glucocorticoid resistance
Critical illness
Sepsis
ICU
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422002389

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