Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology
Worldwide,leptospirosis is the most highly prevalent zoonosis. Although the wide range of clinical manifestations of leptospirosis in humans is well-documented, knowledge of the mechanisms throughwhich this pathogen causes kidney disease remains limited. This narrative review of the...
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| Format: | Article |
| Language: | Spanish |
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Colegio Médico de Honduras
2022-11-01
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| Series: | Revista Médica Hondureña |
| Subjects: | |
| Online Access: | https://www.camjol.info/index.php/RMH/article/view/15201 |
| _version_ | 1797901013317844992 |
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| author | Rafael Guillermo Villarreal-Julio Enderson Murillo Ramos René Ramírez-García Ronald Guillermo Peláez-Sánchez Piedad Matilde Agudelo-Flórez |
| author_facet | Rafael Guillermo Villarreal-Julio Enderson Murillo Ramos René Ramírez-García Ronald Guillermo Peláez-Sánchez Piedad Matilde Agudelo-Flórez |
| author_sort | Rafael Guillermo Villarreal-Julio |
| collection | DOAJ |
| description | Worldwide,leptospirosis is the most highly prevalent zoonosis. Although the wide range of clinical manifestations of leptospirosis in humans is well-documented, knowledge of the mechanisms throughwhich this pathogen causes kidney disease remains limited. This narrative review of the scientific literature presents experimental studies of pathophysiology and kidney disease in leptospirosis, both in humans and animals, and the results show thatvirulence factors are involved in kidney damage by inducinginterstitial tubular nephritis, which is the most frequent pathological manifestation, additionally, to the acute non-oliguric renal lesion withhypokalemia, and loss of magnesium and sodium. Finally, it isconcluded that in leptospirosis, the initial lesion in the kidney is caused bydamage to the cell membrane of the proximal tubular region cells by pathogenic Leptospira virulence factors, thus exacerbating theimmune response. |
| first_indexed | 2024-04-10T08:54:08Z |
| format | Article |
| id | doaj.art-122f4e0896204794bc86cb8b9a3646b2 |
| institution | Directory Open Access Journal |
| issn | 0375-1112 1995-7068 |
| language | Spanish |
| last_indexed | 2024-04-10T08:54:08Z |
| publishDate | 2022-11-01 |
| publisher | Colegio Médico de Honduras |
| record_format | Article |
| series | Revista Médica Hondureña |
| spelling | doaj.art-122f4e0896204794bc86cb8b9a3646b22023-02-21T17:20:49ZspaColegio Médico de HondurasRevista Médica Hondureña0375-11121995-70682022-11-0190216016610.5377/rmh.v90i2.15201Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiologyRafael Guillermo Villarreal-Julio 0https://orcid.org/0000-0002-9009-1086Enderson Murillo Ramos 1https://orcid.org/0000-0001-6790-976XRené Ramírez-García 2https://orcid.org/0000-0002-8026-174XRonald Guillermo Peláez-Sánchez 3https://orcid.org/0000-0002-2815-9844Piedad Matilde Agudelo-Flórez 4https://orcid.org/0000-0002-0002-776XCES University, Graduate School, Molecular Biology Unit, Medellín, Colombia; BIOTECH MOLECULAR, Molecular, Genetic and Computational Biology Unit, Medellín, Colombia; University of Antioquia, School of Medicine, Program for the Study and Control of Tropical Diseases (PECET), Medellín, Colombia University of Antioquia, School of Medicine, Program for the Study and Control of Tropical Diseases (PECET), Medellín, Colombia; University of Antioquia, School of Medicine, Integrated Laboratory of Specialized Medicine (LIME), Medellín, Colombia CES University, Graduate School, Molecular Biology Unit, Medellín, Colombia; CES University, Faculty of Veterinary Medicine and Zootechnics, Medellín, ColombiaCES University, Graduate School, Molecular Biology Unit, Medellín, Colombia CES University, Graduate School, Molecular Biology Unit, Medellín, ColombiaWorldwide,leptospirosis is the most highly prevalent zoonosis. Although the wide range of clinical manifestations of leptospirosis in humans is well-documented, knowledge of the mechanisms throughwhich this pathogen causes kidney disease remains limited. This narrative review of the scientific literature presents experimental studies of pathophysiology and kidney disease in leptospirosis, both in humans and animals, and the results show thatvirulence factors are involved in kidney damage by inducinginterstitial tubular nephritis, which is the most frequent pathological manifestation, additionally, to the acute non-oliguric renal lesion withhypokalemia, and loss of magnesium and sodium. Finally, it isconcluded that in leptospirosis, the initial lesion in the kidney is caused bydamage to the cell membrane of the proximal tubular region cells by pathogenic Leptospira virulence factors, thus exacerbating theimmune response.https://www.camjol.info/index.php/RMH/article/view/15201kyned failure; leptospira; leptospirosis; pathogenesis; virulence factors. |
| spellingShingle | Rafael Guillermo Villarreal-Julio Enderson Murillo Ramos René Ramírez-García Ronald Guillermo Peláez-Sánchez Piedad Matilde Agudelo-Flórez Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology Revista Médica Hondureña kyned failure; leptospira; leptospirosis; pathogenesis; virulence factors. |
| title | Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology |
| title_full | Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology |
| title_fullStr | Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology |
| title_full_unstemmed | Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology |
| title_short | Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology |
| title_sort | narrative review of generalities of the genus leptospira and its virulence factors associated with renal pathophysiology |
| topic | kyned failure; leptospira; leptospirosis; pathogenesis; virulence factors. |
| url | https://www.camjol.info/index.php/RMH/article/view/15201 |
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