Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of reproductive ages. It is associated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (IR), compensatory hyperinsulinemia, gestational, and type 2 diabetes, and increased...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=7;epage=7;aulast=Mehrabian |
| _version_ | 1819160808581496832 |
|---|---|
| author | Ferdous Mehrabian Hatav Ghasemi-Tehrani Mahboobe Mohamadkhani Maryam Moeinoddini Pooya Karimzadeh |
| author_facet | Ferdous Mehrabian Hatav Ghasemi-Tehrani Mahboobe Mohamadkhani Maryam Moeinoddini Pooya Karimzadeh |
| author_sort | Ferdous Mehrabian |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of reproductive ages. It is associated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (IR), compensatory hyperinsulinemia, gestational, and type 2 diabetes, and increased risk of cardiovascular morbidity. There are different treatments available for PCOS. The purpose of this study was to determine and compare the effects of metformin, flutamide plus oral contraceptives (OCs), and simvastatin on the metabolic consequences of PCOS. Materials and Methods: This study was a single-blind clinical trial. The subjects were selected from a group of patient with PCOS and metabolic syndrome, who were referred to the midwifery clinic of Al-Zahra Hospital and Beheshti Hospital, Isfahan, Iran. A total of 111 subjects were randomly assigned to three groups: metformin, flutamide plus OCs, and simvastatin groups. The measurements were performed at baseline and after 6 months of therapy. Paired t-test, analysis of variance (ANOVA), and chi-square test were applied in this study. Results: A total of 102 subjects were analyzed in this study, 34 subjects were allotted in each group. The prevalence of IR was statistically different between three groups (P-value = 0.001). After a 6-month course, metformin showed larger reduction in fasting blood sugar (FBS) level (P-value < 0.001). However, except for metformin, two other treatments reduced C-reactive protein (CRP) level significantly (both P-values < 0.001). The level of triglycerides (TGs) decreased considerably in all groups (all P-values < 0.001). Both metformin and simvastatin decreased BMI significantly (both P-values < 0.001). None of the treatments changed high-density lipoprotein (HDL) level (all P-values > 0.05). Conclusion: Metformin performed better in FBS reduction. Simvastatin had better performance in terms of reducing TG level and waist circumference. |
| first_indexed | 2024-12-22T17:02:20Z |
| format | Article |
| id | doaj.art-1231a52c85b94ed8962d776db86e671e |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-22T17:02:20Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-1231a52c85b94ed8962d776db86e671e2022-12-21T18:19:18ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362016-01-012117710.4103/1735-1995.177354Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndromeFerdous MehrabianHatav Ghasemi-TehraniMahboobe MohamadkhaniMaryam MoeinoddiniPooya KarimzadehBackground: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of reproductive ages. It is associated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (IR), compensatory hyperinsulinemia, gestational, and type 2 diabetes, and increased risk of cardiovascular morbidity. There are different treatments available for PCOS. The purpose of this study was to determine and compare the effects of metformin, flutamide plus oral contraceptives (OCs), and simvastatin on the metabolic consequences of PCOS. Materials and Methods: This study was a single-blind clinical trial. The subjects were selected from a group of patient with PCOS and metabolic syndrome, who were referred to the midwifery clinic of Al-Zahra Hospital and Beheshti Hospital, Isfahan, Iran. A total of 111 subjects were randomly assigned to three groups: metformin, flutamide plus OCs, and simvastatin groups. The measurements were performed at baseline and after 6 months of therapy. Paired t-test, analysis of variance (ANOVA), and chi-square test were applied in this study. Results: A total of 102 subjects were analyzed in this study, 34 subjects were allotted in each group. The prevalence of IR was statistically different between three groups (P-value = 0.001). After a 6-month course, metformin showed larger reduction in fasting blood sugar (FBS) level (P-value < 0.001). However, except for metformin, two other treatments reduced C-reactive protein (CRP) level significantly (both P-values < 0.001). The level of triglycerides (TGs) decreased considerably in all groups (all P-values < 0.001). Both metformin and simvastatin decreased BMI significantly (both P-values < 0.001). None of the treatments changed high-density lipoprotein (HDL) level (all P-values > 0.05). Conclusion: Metformin performed better in FBS reduction. Simvastatin had better performance in terms of reducing TG level and waist circumference.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=7;epage=7;aulast=MehrabianFlutamidemetforminoral contraceptives (OCs)polycystic ovary syndrome (PCOS)simvastatin |
| spellingShingle | Ferdous Mehrabian Hatav Ghasemi-Tehrani Mahboobe Mohamadkhani Maryam Moeinoddini Pooya Karimzadeh Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome Journal of Research in Medical Sciences Flutamide metformin oral contraceptives (OCs) polycystic ovary syndrome (PCOS) simvastatin |
| title | Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| title_full | Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| title_fullStr | Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| title_full_unstemmed | Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| title_short | Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| title_sort | comparison of the effects of metformin flutamide plus oral contraceptives and simvastatin on the metabolic consequences of polycystic ovary syndrome |
| topic | Flutamide metformin oral contraceptives (OCs) polycystic ovary syndrome (PCOS) simvastatin |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=7;epage=7;aulast=Mehrabian |
| work_keys_str_mv | AT ferdousmehrabian comparisonoftheeffectsofmetforminflutamideplusoralcontraceptivesandsimvastatinonthemetabolicconsequencesofpolycysticovarysyndrome AT hatavghasemitehrani comparisonoftheeffectsofmetforminflutamideplusoralcontraceptivesandsimvastatinonthemetabolicconsequencesofpolycysticovarysyndrome AT mahboobemohamadkhani comparisonoftheeffectsofmetforminflutamideplusoralcontraceptivesandsimvastatinonthemetabolicconsequencesofpolycysticovarysyndrome AT maryammoeinoddini comparisonoftheeffectsofmetforminflutamideplusoralcontraceptivesandsimvastatinonthemetabolicconsequencesofpolycysticovarysyndrome AT pooyakarimzadeh comparisonoftheeffectsofmetforminflutamideplusoralcontraceptivesandsimvastatinonthemetabolicconsequencesofpolycysticovarysyndrome |