Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis
Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2016-05-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_id=552&sid=1&slc_lang=en |
| Summary: | Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with
potent anti-inflammatory property, which has been considered as an essential risk factor in the
inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression
of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism
has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide
a relatively comprehensive account of the relation between -509C/T gene polymorphisms of
TGF-β1 and susceptibility to IS.
Methods: A review of literature for eligible genetic association Studies published before October
20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The
strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals
using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared,
and Chi-squared tests.
Results: A total of 2 studies involving 614 cases and 617 controls were found. The overall
estimates did not show any significant relation between TGF-β1-509C/T polymorphism and risk
of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC
vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06,
95%CI=0.55 to 2.04; P=0.86).
Conclusion: This meta-analysis showed that TGF-β1-509C/T gene polymorphism has no
significant association with the susceptibility of IS. Further well-designed prospective studies
with larger sample size are needed to confirm these findings. |
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| ISSN: | 2008-126X 2228-7442 |