Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis
Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2016-05-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_id=552&sid=1&slc_lang=en |
| _version_ | 1797284970434134016 |
|---|---|
| author | Pradeep Kumar Amit Kumar Mukesh Kumar Srivastava Shubham Misra Awadh Kishor Pandit Kameshwar Prasad |
| author_facet | Pradeep Kumar Amit Kumar Mukesh Kumar Srivastava Shubham Misra Awadh Kishor Pandit Kameshwar Prasad |
| author_sort | Pradeep Kumar |
| collection | DOAJ |
| description | Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with
potent anti-inflammatory property, which has been considered as an essential risk factor in the
inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression
of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism
has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide
a relatively comprehensive account of the relation between -509C/T gene polymorphisms of
TGF-β1 and susceptibility to IS.
Methods: A review of literature for eligible genetic association Studies published before October
20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The
strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals
using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared,
and Chi-squared tests.
Results: A total of 2 studies involving 614 cases and 617 controls were found. The overall
estimates did not show any significant relation between TGF-β1-509C/T polymorphism and risk
of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC
vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06,
95%CI=0.55 to 2.04; P=0.86).
Conclusion: This meta-analysis showed that TGF-β1-509C/T gene polymorphism has no
significant association with the susceptibility of IS. Further well-designed prospective studies
with larger sample size are needed to confirm these findings. |
| first_indexed | 2024-03-07T17:55:29Z |
| format | Article |
| id | doaj.art-1234507e62b8410798332a9b7a9ffb04 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:55:29Z |
| publishDate | 2016-05-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-1234507e62b8410798332a9b7a9ffb042024-03-02T12:15:54ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422016-05-01729196Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta AnalysisPradeep Kumar0Amit Kumar1Mukesh Kumar Srivastava2Shubham Misra3Awadh Kishor Pandit4Kameshwar Prasad5Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.Department of Neurobiochemistry, All India Institute of Medical Sciences, New Delhi, India.Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF-β1 and susceptibility to IS. Methods: A review of literature for eligible genetic association Studies published before October 20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared, and Chi-squared tests. Results: A total of 2 studies involving 614 cases and 617 controls were found. The overall estimates did not show any significant relation between TGF-β1-509C/T polymorphism and risk of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06, 95%CI=0.55 to 2.04; P=0.86). Conclusion: This meta-analysis showed that TGF-β1-509C/T gene polymorphism has no significant association with the susceptibility of IS. Further well-designed prospective studies with larger sample size are needed to confirm these findings.http://bcn.iums.ac.ir/browse.php?a_id=552&sid=1&slc_lang=enTransforming growth factor betaCytokineInflammationCerebral infarctionIschemic strokeSingle nucleotide polymorphism |
| spellingShingle | Pradeep Kumar Amit Kumar Mukesh Kumar Srivastava Shubham Misra Awadh Kishor Pandit Kameshwar Prasad Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis Basic and Clinical Neuroscience Transforming growth factor beta Cytokine Inflammation Cerebral infarction Ischemic stroke Single nucleotide polymorphism |
| title | Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis |
| title_full | Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis |
| title_fullStr | Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis |
| title_full_unstemmed | Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis |
| title_short | Review Paper: Association of Transforming Growth Factor Beta-1 -509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis |
| title_sort | review paper association of transforming growth factor beta 1 509c t gene polymorphism with ischemic stroke a meta analysis |
| topic | Transforming growth factor beta Cytokine Inflammation Cerebral infarction Ischemic stroke Single nucleotide polymorphism |
| url | http://bcn.iums.ac.ir/browse.php?a_id=552&sid=1&slc_lang=en |
| work_keys_str_mv | AT pradeepkumar reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis AT amitkumar reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis AT mukeshkumarsrivastava reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis AT shubhammisra reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis AT awadhkishorpandit reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis AT kameshwarprasad reviewpaperassociationoftransforminggrowthfactorbeta1509ctgenepolymorphismwithischemicstrokeametaanalysis |