Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells
The Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/9/871 |
| _version_ | 1797517612122374144 |
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| author | Cristina Trejo-Solis Angel Escamilla-Ramirez Dolores Jimenez-Farfan Rosa Angelica Castillo-Rodriguez Athenea Flores-Najera Arturo Cruz-Salgado |
| author_facet | Cristina Trejo-Solis Angel Escamilla-Ramirez Dolores Jimenez-Farfan Rosa Angelica Castillo-Rodriguez Athenea Flores-Najera Arturo Cruz-Salgado |
| author_sort | Cristina Trejo-Solis |
| collection | DOAJ |
| description | The Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation and apoptosis both through β-catenin-dependent and independent mechanisms, and by crosstalk with other signaling pathways in a wide range of malignant tumors. Existing studies have reported conflicting results, indicating that the Wnt signaling can have both oncogenic and tumor-suppressing roles, depending on the cellular context. This review summarizes the available information on the role of the Wnt/β-catenin pathway and its crosstalk with other signaling pathways in apoptosis induction in cancer cells and presents a modified dual-signal model for the function of β-catenin. Understanding the proapoptotic mechanisms induced by the Wnt/β-catenin pathway could open new therapeutic opportunities. |
| first_indexed | 2024-03-10T07:18:57Z |
| format | Article |
| id | doaj.art-12349269e50b482a8c50ba4b8d22ca6b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T07:18:57Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-12349269e50b482a8c50ba4b8d22ca6b2023-11-22T14:44:40ZengMDPI AGPharmaceuticals1424-82472021-08-0114987110.3390/ph14090871Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer CellsCristina Trejo-Solis0Angel Escamilla-Ramirez1Dolores Jimenez-Farfan2Rosa Angelica Castillo-Rodriguez3Athenea Flores-Najera4Arturo Cruz-Salgado5Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de Mexico 14269, MexicoLaboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de Mexico 14269, MexicoLaboratorio de Inmunología, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, MexicoCONACYT-Instituto Nacional de Pediatría, Ciudad de Mexico 04530, MexicoCentro Médico Nacional 20 de Noviembre, Departamento de Cirugía General, Ciudad de Mexico 03229, MexicoLaboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de Mexico 14269, MexicoThe Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation and apoptosis both through β-catenin-dependent and independent mechanisms, and by crosstalk with other signaling pathways in a wide range of malignant tumors. Existing studies have reported conflicting results, indicating that the Wnt signaling can have both oncogenic and tumor-suppressing roles, depending on the cellular context. This review summarizes the available information on the role of the Wnt/β-catenin pathway and its crosstalk with other signaling pathways in apoptosis induction in cancer cells and presents a modified dual-signal model for the function of β-catenin. Understanding the proapoptotic mechanisms induced by the Wnt/β-catenin pathway could open new therapeutic opportunities.https://www.mdpi.com/1424-8247/14/9/871crosstalkβ-cateninapoptosissignalingcancer cells |
| spellingShingle | Cristina Trejo-Solis Angel Escamilla-Ramirez Dolores Jimenez-Farfan Rosa Angelica Castillo-Rodriguez Athenea Flores-Najera Arturo Cruz-Salgado Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells Pharmaceuticals crosstalk β-catenin apoptosis signaling cancer cells |
| title | Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells |
| title_full | Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells |
| title_fullStr | Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells |
| title_full_unstemmed | Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells |
| title_short | Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells |
| title_sort | crosstalk of the wnt β catenin signaling pathway in the induction of apoptosis on cancer cells |
| topic | crosstalk β-catenin apoptosis signaling cancer cells |
| url | https://www.mdpi.com/1424-8247/14/9/871 |
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