Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP
(1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP ha...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/12/1676 |
| _version_ | 1797380387100426240 |
|---|---|
| author | Ioana Alexandra Zaha Anca Huniadi Florin Bodog Luana Seles Mihaela Cristina Toma Laura Maghiar Erika Szulay-Bimbo Alin Bodog Liliana Sachelarie Mihai Florea Liana Stefan |
| author_facet | Ioana Alexandra Zaha Anca Huniadi Florin Bodog Luana Seles Mihaela Cristina Toma Laura Maghiar Erika Szulay-Bimbo Alin Bodog Liliana Sachelarie Mihai Florea Liana Stefan |
| author_sort | Ioana Alexandra Zaha |
| collection | DOAJ |
| description | (1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP have been shown in recent research to have positive effects on the endometrium. PRP increases the pregnancy rate in IVF patients with thin endometrium and recurrent implantation failure. In order to demonstrate the efficacy of PRP therapies, this work compares the administration of injectable and infusible PRP during endometrial preparation. (2) Methods: This prospective single-arm control study was conducted at an IVF center in Oradea, Romania. This study included 50 patients; 27 were included in the group with Injectable PRP and 23 in the group with Infusible PRP. The outcome was compared between the two groups, with the primary outcome being the endometrial thickness after the PRP infusion or injection and the secondary outcome being the pregnancy rate in both groups. (3) Results: Patients who were treated with Injectable PRP had a higher pregnancy rate. An improvement in the quality of the endometrium, in terms of thickness, was also observed in the patients who were injected with PRP. (4) Conclusions: Compared to PRP infusions inside the uterus, sub-endometrial PRP injections in frozen embryo transfer methods have a greater pregnancy rate. |
| first_indexed | 2024-03-08T20:36:29Z |
| format | Article |
| id | doaj.art-123576dd4668438789a64c1f2dd92697 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T20:36:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-123576dd4668438789a64c1f2dd926972023-12-22T14:19:55ZengMDPI AGJournal of Personalized Medicine2075-44262023-11-011312167610.3390/jpm13121676Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRPIoana Alexandra Zaha0Anca Huniadi1Florin Bodog2Luana Seles3Mihaela Cristina Toma4Laura Maghiar5Erika Szulay-Bimbo6Alin Bodog7Liliana Sachelarie8Mihai Florea9Liana Stefan10Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, RomaniaDepartment of Prelinical Discipline, Apollonia University, 700511 Iasi, RomaniaA Calla—Infertility Diagnostic and Treatment Center, Constantin A. Rosetti Street, 410103 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, Romania(1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP have been shown in recent research to have positive effects on the endometrium. PRP increases the pregnancy rate in IVF patients with thin endometrium and recurrent implantation failure. In order to demonstrate the efficacy of PRP therapies, this work compares the administration of injectable and infusible PRP during endometrial preparation. (2) Methods: This prospective single-arm control study was conducted at an IVF center in Oradea, Romania. This study included 50 patients; 27 were included in the group with Injectable PRP and 23 in the group with Infusible PRP. The outcome was compared between the two groups, with the primary outcome being the endometrial thickness after the PRP infusion or injection and the secondary outcome being the pregnancy rate in both groups. (3) Results: Patients who were treated with Injectable PRP had a higher pregnancy rate. An improvement in the quality of the endometrium, in terms of thickness, was also observed in the patients who were injected with PRP. (4) Conclusions: Compared to PRP infusions inside the uterus, sub-endometrial PRP injections in frozen embryo transfer methods have a greater pregnancy rate.https://www.mdpi.com/2075-4426/13/12/1676thin endometriumPRPfrozen embryo transferendometrial thicknessIVF |
| spellingShingle | Ioana Alexandra Zaha Anca Huniadi Florin Bodog Luana Seles Mihaela Cristina Toma Laura Maghiar Erika Szulay-Bimbo Alin Bodog Liliana Sachelarie Mihai Florea Liana Stefan Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP Journal of Personalized Medicine thin endometrium PRP frozen embryo transfer endometrial thickness IVF |
| title | Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP |
| title_full | Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP |
| title_fullStr | Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP |
| title_full_unstemmed | Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP |
| title_short | Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP |
| title_sort | autologous platelet rich plasma prp in infertility infusion versus injectable prp |
| topic | thin endometrium PRP frozen embryo transfer endometrial thickness IVF |
| url | https://www.mdpi.com/2075-4426/13/12/1676 |
| work_keys_str_mv | AT ioanaalexandrazaha autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT ancahuniadi autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT florinbodog autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT luanaseles autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT mihaelacristinatoma autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT lauramaghiar autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT erikaszulaybimbo autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT alinbodog autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT lilianasachelarie autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT mihaiflorea autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp AT lianastefan autologousplateletrichplasmaprpininfertilityinfusionversusinjectableprp |