Pathomechanisms of bone loss in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease, in which the inflammatory processes involve the skeletal system and there is marked destruction of the bones and the surrounding structures. In this review, we discuss the current concepts of osteoimmunology in RA, which represent the molecular cro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.962969/full |
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| author | Rajalingham Sakthiswary Rajeswaran Uma Veshaaliini Kok-Yong Chin Srijit Das Srinivasa Rao Sirasanagandla |
| author_facet | Rajalingham Sakthiswary Rajeswaran Uma Veshaaliini Kok-Yong Chin Srijit Das Srinivasa Rao Sirasanagandla |
| author_sort | Rajalingham Sakthiswary |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an autoimmune disease, in which the inflammatory processes involve the skeletal system and there is marked destruction of the bones and the surrounding structures. In this review, we discuss the current concepts of osteoimmunology in RA, which represent the molecular crosstalk between the immune and skeletal systems, resulting in the disruption of bone remodeling. Bone loss in RA can be focal or generalized, leading to secondary osteoporosis. We have summarized the recent studies of bone loss in RA, which focused on the molecular aspects, such as cytokines, autoantibodies, receptor activator of nuclear kappa-β ligand (RANKL) and osteoprotegerin (OPG). Apart from the above molecules, the role of aryl hydrocarbon receptor (Ahr), which is a potential key mediator in this process through the generation of the Th17 cells, is discussed. Hence, this review highlights the key insights into molecular mechanisms of bone loss in RA. |
| first_indexed | 2024-12-10T16:25:29Z |
| format | Article |
| id | doaj.art-123577d41f5b40bcbe642ae885dcb80e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T16:25:29Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-123577d41f5b40bcbe642ae885dcb80e2022-12-22T01:41:40ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.962969962969Pathomechanisms of bone loss in rheumatoid arthritisRajalingham Sakthiswary0Rajeswaran Uma Veshaaliini1Kok-Yong Chin2Srijit Das3Srinivasa Rao Sirasanagandla4Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Human and Clinical Anatomy College of Medicine and Health Sciences Sultan Qaboos University, Muscat, OmanDepartment of Human and Clinical Anatomy College of Medicine and Health Sciences Sultan Qaboos University, Muscat, OmanRheumatoid arthritis (RA) is an autoimmune disease, in which the inflammatory processes involve the skeletal system and there is marked destruction of the bones and the surrounding structures. In this review, we discuss the current concepts of osteoimmunology in RA, which represent the molecular crosstalk between the immune and skeletal systems, resulting in the disruption of bone remodeling. Bone loss in RA can be focal or generalized, leading to secondary osteoporosis. We have summarized the recent studies of bone loss in RA, which focused on the molecular aspects, such as cytokines, autoantibodies, receptor activator of nuclear kappa-β ligand (RANKL) and osteoprotegerin (OPG). Apart from the above molecules, the role of aryl hydrocarbon receptor (Ahr), which is a potential key mediator in this process through the generation of the Th17 cells, is discussed. Hence, this review highlights the key insights into molecular mechanisms of bone loss in RA.https://www.frontiersin.org/articles/10.3389/fmed.2022.962969/fullrheumatoid arthritisboneosteoporosiscytokinesligandsautoantibodies |
| spellingShingle | Rajalingham Sakthiswary Rajeswaran Uma Veshaaliini Kok-Yong Chin Srijit Das Srinivasa Rao Sirasanagandla Pathomechanisms of bone loss in rheumatoid arthritis Frontiers in Medicine rheumatoid arthritis bone osteoporosis cytokines ligands autoantibodies |
| title | Pathomechanisms of bone loss in rheumatoid arthritis |
| title_full | Pathomechanisms of bone loss in rheumatoid arthritis |
| title_fullStr | Pathomechanisms of bone loss in rheumatoid arthritis |
| title_full_unstemmed | Pathomechanisms of bone loss in rheumatoid arthritis |
| title_short | Pathomechanisms of bone loss in rheumatoid arthritis |
| title_sort | pathomechanisms of bone loss in rheumatoid arthritis |
| topic | rheumatoid arthritis bone osteoporosis cytokines ligands autoantibodies |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.962969/full |
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