Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
Circadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-lik...
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/374 |
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| author | Xiaomeng Liu Niuben Cao Xinchan Liu Yu Deng Yu Xin Ruobing Fu Xirui Xin Yubo Hou Weixian Yu |
| author_facet | Xiaomeng Liu Niuben Cao Xinchan Liu Yu Deng Yu Xin Ruobing Fu Xirui Xin Yubo Hou Weixian Yu |
| author_sort | Xiaomeng Liu |
| collection | DOAJ |
| description | Circadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-like-1(BMAL1), which is thought to contribute to metabolic disorders and an altered immune system. However, the relationship between CRD and the development of periodontitis was poorly reported. Therefore, this study aimed to investigate the role played by BMAL1 in periodontitis. We used a modified multi-platform approach (MMPM) to induce circadian rhythm disturbances in rats to investigate the role of BMAL1 in periodontitis. Our results showed significant downregulation of BMAL1 in the CRD with periodontitis group, significant resorption of alveolar bone, increased osteoclast differentiation, and upregulation of the inflammatory signaling molecule NF-κB. In addition, apoptosis and oxidative stress levels were increased in periodontal tissues. Collectively, our study suggests that BMAL1 is a key regulator in periodontitis exacerbated by CRD and that CRD may lead to the downregulation of BMAL1, thereby exacerbating oxidative stress and apoptosis in periodontal tissues. Our study found that BMAL1 may be associated with the progression of periodontitis and provides a new perspective on the treatment of periodontitis. |
| first_indexed | 2024-03-11T09:59:33Z |
| format | Article |
| id | doaj.art-1236ac0ffe8c4efa9df3ae7484005f3e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:33Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1236ac0ffe8c4efa9df3ae7484005f3e2023-11-16T15:32:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124137410.3390/ijms24010374Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1Xiaomeng Liu0Niuben Cao1Xinchan Liu2Yu Deng3Yu Xin4Ruobing Fu5Xirui Xin6Yubo Hou7Weixian Yu8Department of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Oral Implantology, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaDepartment of Periodontics, School of Dentistry, Jilin University, Changchun 130021, ChinaCircadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-like-1(BMAL1), which is thought to contribute to metabolic disorders and an altered immune system. However, the relationship between CRD and the development of periodontitis was poorly reported. Therefore, this study aimed to investigate the role played by BMAL1 in periodontitis. We used a modified multi-platform approach (MMPM) to induce circadian rhythm disturbances in rats to investigate the role of BMAL1 in periodontitis. Our results showed significant downregulation of BMAL1 in the CRD with periodontitis group, significant resorption of alveolar bone, increased osteoclast differentiation, and upregulation of the inflammatory signaling molecule NF-κB. In addition, apoptosis and oxidative stress levels were increased in periodontal tissues. Collectively, our study suggests that BMAL1 is a key regulator in periodontitis exacerbated by CRD and that CRD may lead to the downregulation of BMAL1, thereby exacerbating oxidative stress and apoptosis in periodontal tissues. Our study found that BMAL1 may be associated with the progression of periodontitis and provides a new perspective on the treatment of periodontitis.https://www.mdpi.com/1422-0067/24/1/374circadian rhythm disturbancescircadian clockBMAL1periodontitis |
| spellingShingle | Xiaomeng Liu Niuben Cao Xinchan Liu Yu Deng Yu Xin Ruobing Fu Xirui Xin Yubo Hou Weixian Yu Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 International Journal of Molecular Sciences circadian rhythm disturbances circadian clock BMAL1 periodontitis |
| title | Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 |
| title_full | Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 |
| title_fullStr | Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 |
| title_full_unstemmed | Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 |
| title_short | Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 |
| title_sort | circadian rhythm disorders aggravate periodontitis by modulating bmal1 |
| topic | circadian rhythm disturbances circadian clock BMAL1 periodontitis |
| url | https://www.mdpi.com/1422-0067/24/1/374 |
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