The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacteriu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-10-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0009832 |
| _version_ | 1819177730761031680 |
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| author | Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel |
| author_facet | Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel |
| author_sort | Guillain Mikaty |
| collection | DOAJ |
| description | Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague. |
| first_indexed | 2024-12-22T21:31:18Z |
| format | Article |
| id | doaj.art-123b85de85004b59a08967a8c6e7f4dc |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-22T21:31:18Z |
| publishDate | 2021-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-123b85de85004b59a08967a8c6e7f4dc2022-12-21T18:11:55ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-10-011510e000983210.1371/journal.pntd.0009832The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.Guillain MikatyHéloïse CoullonLaurence FietteJavier Pizarro-CerdáElisabeth CarnielYersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague.https://doi.org/10.1371/journal.pntd.0009832 |
| spellingShingle | Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. PLoS Neglected Tropical Diseases |
| title | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. |
| title_full | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. |
| title_fullStr | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. |
| title_full_unstemmed | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. |
| title_short | The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages. |
| title_sort | invasive pathogen yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages |
| url | https://doi.org/10.1371/journal.pntd.0009832 |
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