Effect of Moisture on Powder Flow Properties of Theophylline
Powder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/2/3/275/ |
| _version_ | 1828350251336990720 |
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| author | Niklas Sandler Katharina Reiche Jyrki Heinämäki Jouko Yliruusi |
| author_facet | Niklas Sandler Katharina Reiche Jyrki Heinämäki Jouko Yliruusi |
| author_sort | Niklas Sandler |
| collection | DOAJ |
| description | Powder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor, or in a dosage form consisting of materials (e.g., excipients) that contain water and are capable of transferring in to other ingredients. The effect of moisture on powder flowability depends on the amount of water and its distribution. The aim of this work was to examine the effect of humidity on the flow properties of theophylline using information derived from solid-state analysis of the systems investigated. |
| first_indexed | 2024-04-14T01:22:15Z |
| format | Article |
| id | doaj.art-124003db8a444d20bbd9664c4283fa81 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T01:22:15Z |
| publishDate | 2010-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-124003db8a444d20bbd9664c4283fa812022-12-22T02:20:35ZengMDPI AGPharmaceutics1999-49232010-07-012327529010.3390/pharmaceutics2030275Effect of Moisture on Powder Flow Properties of TheophyllineNiklas SandlerKatharina ReicheJyrki HeinämäkiJouko YliruusiPowder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor, or in a dosage form consisting of materials (e.g., excipients) that contain water and are capable of transferring in to other ingredients. The effect of moisture on powder flowability depends on the amount of water and its distribution. The aim of this work was to examine the effect of humidity on the flow properties of theophylline using information derived from solid-state analysis of the systems investigated.http://www.mdpi.com/1999-4923/2/3/275/powder flowrelative humidityequilibrium moisture contentsolid-state propertiestheophylline |
| spellingShingle | Niklas Sandler Katharina Reiche Jyrki Heinämäki Jouko Yliruusi Effect of Moisture on Powder Flow Properties of Theophylline Pharmaceutics powder flow relative humidity equilibrium moisture content solid-state properties theophylline |
| title | Effect of Moisture on Powder Flow Properties of Theophylline |
| title_full | Effect of Moisture on Powder Flow Properties of Theophylline |
| title_fullStr | Effect of Moisture on Powder Flow Properties of Theophylline |
| title_full_unstemmed | Effect of Moisture on Powder Flow Properties of Theophylline |
| title_short | Effect of Moisture on Powder Flow Properties of Theophylline |
| title_sort | effect of moisture on powder flow properties of theophylline |
| topic | powder flow relative humidity equilibrium moisture content solid-state properties theophylline |
| url | http://www.mdpi.com/1999-4923/2/3/275/ |
| work_keys_str_mv | AT niklassandler effectofmoistureonpowderflowpropertiesoftheophylline AT katharinareiche effectofmoistureonpowderflowpropertiesoftheophylline AT jyrkiheinamaki effectofmoistureonpowderflowpropertiesoftheophylline AT joukoyliruusi effectofmoistureonpowderflowpropertiesoftheophylline |