Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma.

Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma.

Invasive melanoma is the most lethal form of skin cancer. The treatment of melanoma-derived cell lines with 5-aza-2'-deoxycytidine (5-Aza-dC) markedly increases the expression of several miRNAs, suggesting that the miRNA-encoding genes might be epigenetically regulated, either directly or indir...

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Bibliographic Details
Main Authors: Joseph Mazar, Divya Khaitan, Dan DeBlasio, Cuncong Zhong, Subramaniam S Govindarajan, Sharmila Kopanathi, Shaojie Zhang, Animesh Ray, Ranjan J Perera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3176288?pdf=render

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