Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis
Introduction: Adipose tissue is immunologically and hormonally active, and these effects are mediated largely by adipocytokines. Thyroid hormones regulate metabolism and organ function, and Hashimoto’s thyroiditis (HT) is the most common autoimmune disease affecting thyroid function.Ai...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2023-04-01
|
| Series: | Folia Medica |
| Subjects: | |
| Online Access: | https://foliamedica.bg/article/75390/download/pdf/ |
| _version_ | 1797832951194451968 |
|---|---|
| author | Desislav G. Tomov Boryana A. Levterova Dimitar M. Troev Maria Z. Miteva Valentina N. Mihaylova Yordanka I. Uzunova Vidka V. Divarova Maria M. Orbetzova |
| author_facet | Desislav G. Tomov Boryana A. Levterova Dimitar M. Troev Maria Z. Miteva Valentina N. Mihaylova Yordanka I. Uzunova Vidka V. Divarova Maria M. Orbetzova |
| author_sort | Desislav G. Tomov |
| collection | DOAJ |
| description | Introduction: Adipose tissue is immunologically and hormonally active, and these effects are mediated largely by adipocytokines. Thyroid hormones regulate metabolism and organ function, and Hashimoto’s thyroiditis (HT) is the most common autoimmune disease affecting thyroid function.Aim: To evaluate the levels of the adipocytokines leptin and adiponectin in patients with autoimmune HT, and to perform a comparative intragroup analysis in patients with different stages of gland functional activity, and in a control group.Materials and methods: Ninety-five patients with HT and 21 healthy controls were enrolled in the study. Venous blood was taken without anticoagulants after at least 12 hours of fasting, and serum samples were frozen at −70°C until analysis. Serum levels of leptin and adiponectin were determined by an enzyme-linked immunosorbent assay (ELISA).Results: Serum levels of leptin in HT patients were higher than those in the control group (4.5±5.2 ng/mL vs. 1.9±1.3 ng/mL). The hypothyroid patient’s group showed significantly higher levels of leptin than those of the healthy controls (5.1±5.2 ng/mL vs. 1.9±1.3 ng/mL), (p=0.031). Leptin levels correlated positively with body mass index (r=0.533, p<0.001), triglycerides (r=0.223, p=0.033), and immunoreactive insulin (r=0.488, p<0.001) levels. Serum adiponectin concentrations were higher in euthyroid HT patients than in the other groups, but the difference was not statistically significant (p=0.68). We found a positive correlation between adiponectin and HDL cholesterol levels (r=0.442, p<0.001), and negative with body mass index (r=−0.217, p=0.03), and immunoreactive insulin (r=−0.341, p=0.002).Conclusions: The results of this study suggest that leptin has a stronger effect than adiponectin in Hashimoto’s thyroiditis, which can be used to develop new therapeutic agents that modify its effect in the organism. |
| first_indexed | 2024-04-09T14:15:55Z |
| format | Article |
| id | doaj.art-12414e2507d5406d85336557f52719c7 |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-04-09T14:15:55Z |
| publishDate | 2023-04-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-12414e2507d5406d85336557f52719c72023-05-05T08:11:13ZengPensoft PublishersFolia Medica1314-21432023-04-0165219920610.3897/folmed.65.e7539075390Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditisDesislav G. Tomov0Boryana A. Levterova1Dimitar M. Troev2Maria Z. Miteva3Valentina N. Mihaylova4Yordanka I. Uzunova5Vidka V. Divarova6Maria M. Orbetzova7Medical University of PlovdivMedical University of PlovdivClinic of Endocrinology and Metabolic Diseases, St George University HospitalMedical University of PlovdivMedical University of PlovdivMedical University of PlovdivMedical University of PlovdivMedical University of PlovdivIntroduction: Adipose tissue is immunologically and hormonally active, and these effects are mediated largely by adipocytokines. Thyroid hormones regulate metabolism and organ function, and Hashimoto’s thyroiditis (HT) is the most common autoimmune disease affecting thyroid function.Aim: To evaluate the levels of the adipocytokines leptin and adiponectin in patients with autoimmune HT, and to perform a comparative intragroup analysis in patients with different stages of gland functional activity, and in a control group.Materials and methods: Ninety-five patients with HT and 21 healthy controls were enrolled in the study. Venous blood was taken without anticoagulants after at least 12 hours of fasting, and serum samples were frozen at −70°C until analysis. Serum levels of leptin and adiponectin were determined by an enzyme-linked immunosorbent assay (ELISA).Results: Serum levels of leptin in HT patients were higher than those in the control group (4.5±5.2 ng/mL vs. 1.9±1.3 ng/mL). The hypothyroid patient’s group showed significantly higher levels of leptin than those of the healthy controls (5.1±5.2 ng/mL vs. 1.9±1.3 ng/mL), (p=0.031). Leptin levels correlated positively with body mass index (r=0.533, p<0.001), triglycerides (r=0.223, p=0.033), and immunoreactive insulin (r=0.488, p<0.001) levels. Serum adiponectin concentrations were higher in euthyroid HT patients than in the other groups, but the difference was not statistically significant (p=0.68). We found a positive correlation between adiponectin and HDL cholesterol levels (r=0.442, p<0.001), and negative with body mass index (r=−0.217, p=0.03), and immunoreactive insulin (r=−0.341, p=0.002).Conclusions: The results of this study suggest that leptin has a stronger effect than adiponectin in Hashimoto’s thyroiditis, which can be used to develop new therapeutic agents that modify its effect in the organism.https://foliamedica.bg/article/75390/download/pdf/adipocytokinesHashimoto’s thyroiditis |
| spellingShingle | Desislav G. Tomov Boryana A. Levterova Dimitar M. Troev Maria Z. Miteva Valentina N. Mihaylova Yordanka I. Uzunova Vidka V. Divarova Maria M. Orbetzova Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis Folia Medica adipocytokines Hashimoto’s thyroiditis |
| title | Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis |
| title_full | Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis |
| title_fullStr | Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis |
| title_full_unstemmed | Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis |
| title_short | Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis |
| title_sort | serum levels of leptin and adiponectin in patients with autoimmune hashimoto amp 39 s thyroiditis |
| topic | adipocytokines Hashimoto’s thyroiditis |
| url | https://foliamedica.bg/article/75390/download/pdf/ |
| work_keys_str_mv | AT desislavgtomov serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT boryanaalevterova serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT dimitarmtroev serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT mariazmiteva serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT valentinanmihaylova serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT yordankaiuzunova serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT vidkavdivarova serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis AT mariamorbetzova serumlevelsofleptinandadiponectininpatientswithautoimmunehashimotoamp39sthyroiditis |