Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia
This research was aimed at investigating the features of free radical activity and the parameters of glutathione metabolism in tumor tissues and the peritumoral zone at different degrees of glial tumor anaplasia. We analyzed postoperative material from 20 patients with gliomas of different degrees o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/12/439 |
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| author | Larisa Obukhova Tatiana Kopytova Elena Murach Natalya Shchelchkova Claudia Kontorshchikova Igor Medyanik Natalia Orlinskaya Artem Grishin Michael Kontorshchikov Dariya Badanina |
| author_facet | Larisa Obukhova Tatiana Kopytova Elena Murach Natalya Shchelchkova Claudia Kontorshchikova Igor Medyanik Natalia Orlinskaya Artem Grishin Michael Kontorshchikov Dariya Badanina |
| author_sort | Larisa Obukhova |
| collection | DOAJ |
| description | This research was aimed at investigating the features of free radical activity and the parameters of glutathione metabolism in tumor tissues and the peritumoral zone at different degrees of glial tumor anaplasia. We analyzed postoperative material from 20 patients with gliomas of different degrees of anaplasia. The greatest differences compared to adjacent noncancerous tissues were found in the tumor tissue: an increased amount of glutathione and glutathione-related enzymes at Grades I and II, and a decrease of these parameters at Grades III and IV. For the peritumoral zone of Grades I and II, the indices changed in different directions, while for Grades III and IV, they occurred synchronously with the tumor tissue changes. For Low Grade and High Grade gliomas, opposite trends were revealed regarding changes in the level of glutathione and the enzymes involved in its metabolism and in the free radical activity in the peritumoral zone. The content of glutathione and the enzymes involved in its metabolism decreased with the increasing degree of glioma anaplasia. In contrast, free radical activity increased. The glutathione system is an active participant in the antioxidant defense of the body and can be used to characterize the cell condition of gliomas at different stages of tumor development. |
| first_indexed | 2024-03-09T17:11:04Z |
| format | Article |
| id | doaj.art-1241dd0985b04a1784b8141e074f543d |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T17:11:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-1241dd0985b04a1784b8141e074f543d2023-11-24T14:04:05ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-12-0144126439644910.3390/cimb44120439Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of AnaplasiaLarisa Obukhova0Tatiana Kopytova1Elena Murach2Natalya Shchelchkova3Claudia Kontorshchikova4Igor Medyanik5Natalia Orlinskaya6Artem Grishin7Michael Kontorshchikov8Dariya Badanina9Federal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, RussiaThis research was aimed at investigating the features of free radical activity and the parameters of glutathione metabolism in tumor tissues and the peritumoral zone at different degrees of glial tumor anaplasia. We analyzed postoperative material from 20 patients with gliomas of different degrees of anaplasia. The greatest differences compared to adjacent noncancerous tissues were found in the tumor tissue: an increased amount of glutathione and glutathione-related enzymes at Grades I and II, and a decrease of these parameters at Grades III and IV. For the peritumoral zone of Grades I and II, the indices changed in different directions, while for Grades III and IV, they occurred synchronously with the tumor tissue changes. For Low Grade and High Grade gliomas, opposite trends were revealed regarding changes in the level of glutathione and the enzymes involved in its metabolism and in the free radical activity in the peritumoral zone. The content of glutathione and the enzymes involved in its metabolism decreased with the increasing degree of glioma anaplasia. In contrast, free radical activity increased. The glutathione system is an active participant in the antioxidant defense of the body and can be used to characterize the cell condition of gliomas at different stages of tumor development.https://www.mdpi.com/1467-3045/44/12/439glutathioneglutathione reductaseglutathione transferaseglutathione peroxidasefree radical activityperitumoral zone |
| spellingShingle | Larisa Obukhova Tatiana Kopytova Elena Murach Natalya Shchelchkova Claudia Kontorshchikova Igor Medyanik Natalia Orlinskaya Artem Grishin Michael Kontorshchikov Dariya Badanina Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia Current Issues in Molecular Biology glutathione glutathione reductase glutathione transferase glutathione peroxidase free radical activity peritumoral zone |
| title | Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia |
| title_full | Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia |
| title_fullStr | Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia |
| title_full_unstemmed | Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia |
| title_short | Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia |
| title_sort | glutathione and its metabolic enzymes in gliomal tumor tissue and the peritumoral zone at different degrees of anaplasia |
| topic | glutathione glutathione reductase glutathione transferase glutathione peroxidase free radical activity peritumoral zone |
| url | https://www.mdpi.com/1467-3045/44/12/439 |
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