Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction
Abstract Compared to healthy volunteers, participants with post‐acute sequelae of SARS‐CoV‐2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Pulmonary Circulation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pul2.12356 |
| _version_ | 1797236696537890816 |
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| author | George A. Alba Iris Y. Zhou Molly Mascia Michael Magaletta Jehan W. Alladina Francesca L. Giacona Leo C. Ginns Peter Caravan Bradley A. Maron Sydney B. Montesi |
| author_facet | George A. Alba Iris Y. Zhou Molly Mascia Michael Magaletta Jehan W. Alladina Francesca L. Giacona Leo C. Ginns Peter Caravan Bradley A. Maron Sydney B. Montesi |
| author_sort | George A. Alba |
| collection | DOAJ |
| description | Abstract Compared to healthy volunteers, participants with post‐acute sequelae of SARS‐CoV‐2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC. |
| first_indexed | 2024-04-24T17:07:57Z |
| format | Article |
| id | doaj.art-12422b0881fd4dc08ae772bf641eb802 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-24T17:07:57Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-12422b0881fd4dc08ae772bf641eb8022024-03-28T19:28:30ZengWileyPulmonary Circulation2045-89402024-01-01141n/an/a10.1002/pul2.12356Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunctionGeorge A. Alba0Iris Y. Zhou1Molly Mascia2Michael Magaletta3Jehan W. Alladina4Francesca L. Giacona5Leo C. Ginns6Peter Caravan7Bradley A. Maron8Sydney B. Montesi9Harvard Medical School Boston Massachusetts USAHarvard Medical School Boston Massachusetts USAHarvard Medical School Boston Massachusetts USADepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Boston Massachusetts USAHarvard Medical School Boston Massachusetts USADivision of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USAHarvard Medical School Boston Massachusetts USAHarvard Medical School Boston Massachusetts USADivision of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USAHarvard Medical School Boston Massachusetts USAAbstract Compared to healthy volunteers, participants with post‐acute sequelae of SARS‐CoV‐2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.https://doi.org/10.1002/pul2.12356NEDD9post‐acute sequelae of SARS‐CoV‐2 infectionpulmonary vascular dysfunction |
| spellingShingle | George A. Alba Iris Y. Zhou Molly Mascia Michael Magaletta Jehan W. Alladina Francesca L. Giacona Leo C. Ginns Peter Caravan Bradley A. Maron Sydney B. Montesi Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction Pulmonary Circulation NEDD9 post‐acute sequelae of SARS‐CoV‐2 infection pulmonary vascular dysfunction |
| title | Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction |
| title_full | Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction |
| title_fullStr | Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction |
| title_full_unstemmed | Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction |
| title_short | Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction |
| title_sort | plasma nedd9 is increased following sars cov 2 infection and associates with indices of pulmonary vascular dysfunction |
| topic | NEDD9 post‐acute sequelae of SARS‐CoV‐2 infection pulmonary vascular dysfunction |
| url | https://doi.org/10.1002/pul2.12356 |
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