Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
Background Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. Methods and Results We analyzed repeated measures of IMT, blood pressure, and c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.015396 |
| _version_ | 1811332680624635904 |
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| author | Ajoy C. Karikkineth Majd AlGhatrif Matt T. Oberdier Chris Morrell Elango Palchamy James B. Strait Luigi Ferrucci Edward G. Lakatta |
| author_facet | Ajoy C. Karikkineth Majd AlGhatrif Matt T. Oberdier Chris Morrell Elango Palchamy James B. Strait Luigi Ferrucci Edward G. Lakatta |
| author_sort | Ajoy C. Karikkineth |
| collection | DOAJ |
| description | Background Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. Methods and Results We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change (Change) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMTChange with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMTChange was positively associated with baseline low‐density lipoprotein, low‐density lipoproteinChange, and baseline systolic blood pressure and systolic blood pressureChange, but inversely with baseline diastolic blood pressure and diastolic blood pressureChange. When blood pressure was expressed as pulse pressure and MAP, IMTChange was positively associated with baseline pulse pressure and pulse pressureChange and inversely with baseline mean arterial pressure and mean arterial pressureChange. In sex‐specific analysis, these associations were observed in women, but not in men. Conclusions In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men. |
| first_indexed | 2024-04-13T16:40:37Z |
| format | Article |
| id | doaj.art-1242c1535a0e4479913c834d87313a97 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:40:37Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-1242c1535a0e4479913c834d87313a972022-12-22T02:39:15ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-11-0192210.1161/JAHA.119.015396Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on AgingAjoy C. Karikkineth0Majd AlGhatrif1Matt T. Oberdier2Chris Morrell3Elango Palchamy4James B. Strait5Luigi Ferrucci6Edward G. Lakatta7Longitudinal Studies Section Translational Gerontology Branch National Institute on Aging, NIH Baltimore MDLongitudinal Studies Section Translational Gerontology Branch National Institute on Aging, NIH Baltimore MDLongitudinal Studies Section Translational Gerontology Branch National Institute on Aging, NIH Baltimore MDLaboratory of Cardiovascular Science National Institute on Aging NIH Biomedical Research Center Baltimore MDLongitudinal Studies Section Translational Gerontology Branch National Institute on Aging, NIH Baltimore MDLaboratory of Cardiovascular Science National Institute on Aging NIH Biomedical Research Center Baltimore MDLongitudinal Studies Section Translational Gerontology Branch National Institute on Aging, NIH Baltimore MDLaboratory of Cardiovascular Science National Institute on Aging NIH Biomedical Research Center Baltimore MDBackground Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. Methods and Results We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change (Change) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMTChange with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMTChange was positively associated with baseline low‐density lipoprotein, low‐density lipoproteinChange, and baseline systolic blood pressure and systolic blood pressureChange, but inversely with baseline diastolic blood pressure and diastolic blood pressureChange. When blood pressure was expressed as pulse pressure and MAP, IMTChange was positively associated with baseline pulse pressure and pulse pressureChange and inversely with baseline mean arterial pressure and mean arterial pressureChange. In sex‐specific analysis, these associations were observed in women, but not in men. Conclusions In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men.https://www.ahajournals.org/doi/10.1161/JAHA.119.015396aginghypertensionintima‐medial thicknesslongitudinal |
| spellingShingle | Ajoy C. Karikkineth Majd AlGhatrif Matt T. Oberdier Chris Morrell Elango Palchamy James B. Strait Luigi Ferrucci Edward G. Lakatta Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aging hypertension intima‐medial thickness longitudinal |
| title | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
| title_full | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
| title_fullStr | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
| title_full_unstemmed | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
| title_short | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
| title_sort | sex differences in longitudinal determinants of carotid intima medial thickening with aging in a community dwelling population the baltimore longitudinal study on aging |
| topic | aging hypertension intima‐medial thickness longitudinal |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.015396 |
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