Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives
Abstract Characterized by hepatic lipid accumulation, non‐alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non‐alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Benefiting from recent advances in omics t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-05-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20220029 |
| _version_ | 1797796706086027264 |
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| author | Zhengyi Zhu Yuyan Chen Xueqian Qin Shujun Liu Jinglin Wang Haozhen Ren |
| author_facet | Zhengyi Zhu Yuyan Chen Xueqian Qin Shujun Liu Jinglin Wang Haozhen Ren |
| author_sort | Zhengyi Zhu |
| collection | DOAJ |
| description | Abstract Characterized by hepatic lipid accumulation, non‐alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non‐alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Benefiting from recent advances in omics technologies, such as high‐throughput sequencing, voluminous profiling data in HCC‐integrated molecular science into clinical medicine helped clinicians with rational guidance for treatments. In this review, we conclude the majority of publicly available omics data on the NAFLD‐related disease spectrum and bring up new insights to inspire next‐generation therapeutics against this increasingly prevalent disease spectrum in the post‐genomic era. |
| first_indexed | 2024-03-13T03:37:06Z |
| format | Article |
| id | doaj.art-124302d2eaab4eef8920c3f23d81f892 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-13T03:37:06Z |
| publishDate | 2023-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-124302d2eaab4eef8920c3f23d81f8922023-06-23T15:10:28ZengWiley-VCHSmart Medicine2751-18712023-05-0122n/an/a10.1002/SMMD.20220029Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectivesZhengyi Zhu0Yuyan Chen1Xueqian Qin2Shujun Liu3Jinglin Wang4Haozhen Ren5Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaDepartment of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaDepartment of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaDepartment of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaDepartment of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaDepartment of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing ChinaAbstract Characterized by hepatic lipid accumulation, non‐alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non‐alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Benefiting from recent advances in omics technologies, such as high‐throughput sequencing, voluminous profiling data in HCC‐integrated molecular science into clinical medicine helped clinicians with rational guidance for treatments. In this review, we conclude the majority of publicly available omics data on the NAFLD‐related disease spectrum and bring up new insights to inspire next‐generation therapeutics against this increasingly prevalent disease spectrum in the post‐genomic era.https://doi.org/10.1002/SMMD.20220029HCCNAFLDNASHomics datasequencing |
| spellingShingle | Zhengyi Zhu Yuyan Chen Xueqian Qin Shujun Liu Jinglin Wang Haozhen Ren Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives Smart Medicine HCC NAFLD NASH omics data sequencing |
| title | Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives |
| title_full | Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives |
| title_fullStr | Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives |
| title_full_unstemmed | Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives |
| title_short | Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives |
| title_sort | multidimensional landscape of non alcoholic fatty liver disease related disease spectrum uncovered by big omics data profiling evidence and new perspectives |
| topic | HCC NAFLD NASH omics data sequencing |
| url | https://doi.org/10.1002/SMMD.20220029 |
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