Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study
Previous studies have suggested that phthalates are associated with birth weight. However, most phthalate metabolites have not been fully explored. Therefore, we conducted this meta-analysis to assess the relationship between phthalate exposure and birth weight. We identified original studies that m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132300711X |
| _version_ | 1797744109787545600 |
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| author | Shihao Jin Shanshan Cui Jinghan Xu Xin Zhang |
| author_facet | Shihao Jin Shanshan Cui Jinghan Xu Xin Zhang |
| author_sort | Shihao Jin |
| collection | DOAJ |
| description | Previous studies have suggested that phthalates are associated with birth weight. However, most phthalate metabolites have not been fully explored. Therefore, we conducted this meta-analysis to assess the relationship between phthalate exposure and birth weight. We identified original studies that measured phthalate exposure and reported its association with infant birth weight in relevant databases. Regression coefficients (β) with 95% confidence intervals (CIs) were extracted and analyzed for risk estimation. Fixed-effects (I2 ≤ 50%) or random-effects (I2 > 50%) models were adopted according to their heterogeneity. Overall summary estimates indicated negative associations of prenatal exposure to mono-n-butyl phthalate (pooled β = −11.34 g; 95% CI: −20.98 to −1.70 g) and mono-methyl phthalate (pooled β = −8.78 g; 95% CI: −16.30 to −1.27 g). No statistical association was found between the other less commonly used phthalate metabolites and birth weight. Subgroup analyses indicated that exposure to mono-n-butyl phthalate was associated with birth weight in females (β = −10.74 g; 95% CI: −18.70 to −2.79 g). Our findings indicate that phthalate exposure might be a risk factor for low birth weight and that this relationship may be sex specific. More research is needed to promote preventive policies regarding the potential health hazards of phthalates. |
| first_indexed | 2024-03-12T15:05:01Z |
| format | Article |
| id | doaj.art-1244450c6f2e4f52b26e1a043560bf40 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:01Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-1244450c6f2e4f52b26e1a043560bf402023-08-13T04:51:58ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115207Associations between prenatal exposure to phthalates and birth weight: A meta-analysis studyShihao Jin0Shanshan Cui1Jinghan Xu2Xin Zhang3Department of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, PR ChinaSchool of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, PR ChinaDepartment of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, PR China; Corresponding author.Previous studies have suggested that phthalates are associated with birth weight. However, most phthalate metabolites have not been fully explored. Therefore, we conducted this meta-analysis to assess the relationship between phthalate exposure and birth weight. We identified original studies that measured phthalate exposure and reported its association with infant birth weight in relevant databases. Regression coefficients (β) with 95% confidence intervals (CIs) were extracted and analyzed for risk estimation. Fixed-effects (I2 ≤ 50%) or random-effects (I2 > 50%) models were adopted according to their heterogeneity. Overall summary estimates indicated negative associations of prenatal exposure to mono-n-butyl phthalate (pooled β = −11.34 g; 95% CI: −20.98 to −1.70 g) and mono-methyl phthalate (pooled β = −8.78 g; 95% CI: −16.30 to −1.27 g). No statistical association was found between the other less commonly used phthalate metabolites and birth weight. Subgroup analyses indicated that exposure to mono-n-butyl phthalate was associated with birth weight in females (β = −10.74 g; 95% CI: −18.70 to −2.79 g). Our findings indicate that phthalate exposure might be a risk factor for low birth weight and that this relationship may be sex specific. More research is needed to promote preventive policies regarding the potential health hazards of phthalates.http://www.sciencedirect.com/science/article/pii/S014765132300711XPhthalatesBirth weightMeta-analysis |
| spellingShingle | Shihao Jin Shanshan Cui Jinghan Xu Xin Zhang Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study Ecotoxicology and Environmental Safety Phthalates Birth weight Meta-analysis |
| title | Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study |
| title_full | Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study |
| title_fullStr | Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study |
| title_full_unstemmed | Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study |
| title_short | Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study |
| title_sort | associations between prenatal exposure to phthalates and birth weight a meta analysis study |
| topic | Phthalates Birth weight Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S014765132300711X |
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