Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review
The review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action, effi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1393182/full |
| _version_ | 1797226398446780416 |
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| author | Ana Karina Zambrano Elius Paz-Cruz Viviana A. Ruiz-Pozo Santiago Cadena-Ullauri Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Raynier Zambrano-Villacres Daniel Simancas-Racines |
| author_facet | Ana Karina Zambrano Elius Paz-Cruz Viviana A. Ruiz-Pozo Santiago Cadena-Ullauri Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Raynier Zambrano-Villacres Daniel Simancas-Racines |
| author_sort | Ana Karina Zambrano |
| collection | DOAJ |
| description | The review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action, efficacy, and safety profiles including Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Laparoscopic Adjustable Gastric Banding (LAGB), and Biliopancreatic Diversion (BPD). RYGB and SG are the most prevalent procedures globally, inducing gut microbiota changes that influence microbial diversity and abundance. Post-surgery, alterations in bacterial communities occur, such as the increased of Escherichia coli inversely correlated with fat mass and leptin levels. During digestion, microbiota produce physiologically active compounds like bile acids (Bas) and short-chain fatty acids (SCFAs). SCFAs, derived by microbial fermentation, influence appetite, energy metabolism, and obesity-related pathways. Bas, altered by surgery, modulate glucose metabolism and insulin sensitivity. Furthermore, SG and RYGB enhance incretin secretion, particularly glucagon-like peptide 1 (GLP-1). Therefore, understanding microbiota changes after bariatric surgery could be crucial for predicting metabolic outcomes and developing targeted interventions for obesity management. |
| first_indexed | 2024-04-24T14:24:16Z |
| format | Article |
| id | doaj.art-1245e5739161480ba86785339003ac96 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-24T14:24:16Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1245e5739161480ba86785339003ac962024-04-03T05:12:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-04-011110.3389/fnut.2024.13931821393182Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive reviewAna Karina Zambrano0Elius Paz-Cruz1Viviana A. Ruiz-Pozo2Santiago Cadena-Ullauri3Rafael Tamayo-Trujillo4Patricia Guevara-Ramírez5Raynier Zambrano-Villacres6Daniel Simancas-Racines7Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorFacultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorFacultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorFacultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorFacultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorFacultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, EcuadorUniversidad Espíritu Santo, Samborondón, EcuadorCentro de Investigación de Salud Pública y Epidemiología Clínica (CISPEC), Universidad UTE, Quito, EcuadorThe review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action, efficacy, and safety profiles including Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Laparoscopic Adjustable Gastric Banding (LAGB), and Biliopancreatic Diversion (BPD). RYGB and SG are the most prevalent procedures globally, inducing gut microbiota changes that influence microbial diversity and abundance. Post-surgery, alterations in bacterial communities occur, such as the increased of Escherichia coli inversely correlated with fat mass and leptin levels. During digestion, microbiota produce physiologically active compounds like bile acids (Bas) and short-chain fatty acids (SCFAs). SCFAs, derived by microbial fermentation, influence appetite, energy metabolism, and obesity-related pathways. Bas, altered by surgery, modulate glucose metabolism and insulin sensitivity. Furthermore, SG and RYGB enhance incretin secretion, particularly glucagon-like peptide 1 (GLP-1). Therefore, understanding microbiota changes after bariatric surgery could be crucial for predicting metabolic outcomes and developing targeted interventions for obesity management.https://www.frontiersin.org/articles/10.3389/fnut.2024.1393182/fullbariatric surgerygut microbiotaobesitymicrobiota dynamicsobesity treatment |
| spellingShingle | Ana Karina Zambrano Elius Paz-Cruz Viviana A. Ruiz-Pozo Santiago Cadena-Ullauri Rafael Tamayo-Trujillo Patricia Guevara-Ramírez Raynier Zambrano-Villacres Daniel Simancas-Racines Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review Frontiers in Nutrition bariatric surgery gut microbiota obesity microbiota dynamics obesity treatment |
| title | Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review |
| title_full | Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review |
| title_fullStr | Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review |
| title_full_unstemmed | Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review |
| title_short | Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review |
| title_sort | microbiota dynamics preceding bariatric surgery as obesity treatment a comprehensive review |
| topic | bariatric surgery gut microbiota obesity microbiota dynamics obesity treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1393182/full |
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