Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy
The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6392 |
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| author | Nikita Suvorov Viktor Pogorilyy Ekaterina Diachkova Yuri Vasil’ev Andrey Mironov Mikhail Grin |
| author_facet | Nikita Suvorov Viktor Pogorilyy Ekaterina Diachkova Yuri Vasil’ev Andrey Mironov Mikhail Grin |
| author_sort | Nikita Suvorov |
| collection | DOAJ |
| description | The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT. |
| first_indexed | 2024-03-10T10:24:04Z |
| format | Article |
| id | doaj.art-1246a023f7594e12976888ab02ffa002 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:24:04Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1246a023f7594e12976888ab02ffa0022023-11-22T00:10:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212639210.3390/ijms22126392Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic TherapyNikita Suvorov0Viktor Pogorilyy1Ekaterina Diachkova2Yuri Vasil’ev3Andrey Mironov4Mikhail Grin5Department of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, RussiaDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, RussiaDepartment of Oral Surgery of Bororovsky Institute of Dentistry, II.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St. bldg. 8\2, 119435 Moscow, RussiaDepartment of Operative Surgery and Topographic Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St. bldg. 8\2, 119435 Moscow, RussiaDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, RussiaDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technology, MIREA-Russian Technological University, 119571 Moscow, RussiaThe rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.https://www.mdpi.com/1422-0067/22/12/6392photodynamic therapy (PDT)photosensitizers (PS)antimicrobial PDTchlorophyllbacteriochlorophyll |
| spellingShingle | Nikita Suvorov Viktor Pogorilyy Ekaterina Diachkova Yuri Vasil’ev Andrey Mironov Mikhail Grin Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy International Journal of Molecular Sciences photodynamic therapy (PDT) photosensitizers (PS) antimicrobial PDT chlorophyll bacteriochlorophyll |
| title | Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy |
| title_full | Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy |
| title_fullStr | Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy |
| title_full_unstemmed | Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy |
| title_short | Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy |
| title_sort | derivatives of natural chlorophylls as agents for antimicrobial photodynamic therapy |
| topic | photodynamic therapy (PDT) photosensitizers (PS) antimicrobial PDT chlorophyll bacteriochlorophyll |
| url | https://www.mdpi.com/1422-0067/22/12/6392 |
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