Ascorbic acid 6-palmitate modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated BV-2 cells via PERK/elF2α mediated endoplasmic reticulum stress

Ascorbic acid 6-palmitate modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated BV-2 cells via PERK/elF2α mediated endoplasmic reticulum stress

Abstract Background Neuroinflammation-mediated microglia polarization is a major process in various central nervous system (CNS) diseases. Endoplasmic reticulum (ER) stress contributes to the inflammatory signals as well as to microglia polarization in lipopolysaccharide (LPS) induced neuroinflammat...

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Bibliographic Details
Main Authors: Qian Li, Yao Wu, Xue-shen Chen, Tao Zeng, Lin-ling Liu, Zi-qi Feng, Dan-yang Liu, Ling Zhu, Li-hong Wan
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Ascorbic acid 6-palmitate (L-AP)
M1/M2 polarization
ER stress
PERK/elF2α
Online Access:https://doi.org/10.1186/s12906-022-03780-1

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