The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
Skin is the largest organ of the human body. Its architecture and physiological functions depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis and repair. While several ste...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/5/411 |
| _version_ | 1797712443353333760 |
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| author | Emanuel Rognoni Gernot Walko |
| author_facet | Emanuel Rognoni Gernot Walko |
| author_sort | Emanuel Rognoni |
| collection | DOAJ |
| description | Skin is the largest organ of the human body. Its architecture and physiological functions depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis and repair. While several stem cell populations have been identified in the epidermis with distinct locations and functions, there is additional heterogeneity within the mesenchymal cells of the dermis. Here, we discuss the current knowledge of how the Hippo pathway and its downstream effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) contribute to the maintenance, activation and coordination of the epidermal and dermal cell populations during development, homeostasis, wound healing and cancer. |
| first_indexed | 2024-03-12T07:20:52Z |
| format | Article |
| id | doaj.art-12475807a98a474fbd269d31b089b476 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:20:52Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-12475807a98a474fbd269d31b089b4762023-09-02T22:23:08ZengMDPI AGCells2073-44092019-05-018541110.3390/cells8050411cells8050411The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased SkinEmanuel Rognoni0Gernot Walko1Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UKDepartment of Biology and Biochemistry & Centre for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UKSkin is the largest organ of the human body. Its architecture and physiological functions depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis and repair. While several stem cell populations have been identified in the epidermis with distinct locations and functions, there is additional heterogeneity within the mesenchymal cells of the dermis. Here, we discuss the current knowledge of how the Hippo pathway and its downstream effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) contribute to the maintenance, activation and coordination of the epidermal and dermal cell populations during development, homeostasis, wound healing and cancer.https://www.mdpi.com/2073-4409/8/5/411Hippo signallingskin developmentstem cellsskin cancerfibroblastsfibrosiswound healing |
| spellingShingle | Emanuel Rognoni Gernot Walko The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin Cells Hippo signalling skin development stem cells skin cancer fibroblasts fibrosis wound healing |
| title | The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin |
| title_full | The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin |
| title_fullStr | The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin |
| title_full_unstemmed | The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin |
| title_short | The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin |
| title_sort | roles of yap taz and the hippo pathway in healthy and diseased skin |
| topic | Hippo signalling skin development stem cells skin cancer fibroblasts fibrosis wound healing |
| url | https://www.mdpi.com/2073-4409/8/5/411 |
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