Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration
In this work, physical cross-linking was used to create nanocomposite hydrogels composed of unmodified gum arabic (GA), chitosan (Ch), and natural nanohydroxyapatite (nHA), using an acrylic acid (AA) solvent. Different GA/chitosan contents (15%, 25%, and 35% of the used AA) as well as different nHA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/15/3052 |
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| author | Lara E. Makar Norhan Nady Ahmed Abd El-Fattah Neivin Shawky Sherif H. Kandil |
| author_facet | Lara E. Makar Norhan Nady Ahmed Abd El-Fattah Neivin Shawky Sherif H. Kandil |
| author_sort | Lara E. Makar |
| collection | DOAJ |
| description | In this work, physical cross-linking was used to create nanocomposite hydrogels composed of unmodified gum arabic (GA), chitosan (Ch), and natural nanohydroxyapatite (nHA), using an acrylic acid (AA) solvent. Different GA/chitosan contents (15%, 25%, and 35% of the used AA) as well as different nHA contents (2, 5, and 10 wt.%), were used and studied. The natural nHA and the fabricated GA/Ch/nHA nanocomposite hydrogels were characterized using different analysis techniques. Using acrylic acid solvent produced novel hydrogels with compressive strength of 15.43–22.20 MPa which is similar to that of natural cortical bone. The addition of natural nHA to the hydrogels resulted in a significant improvement in the compressive strength of the fabricated hydrogels. In vitro studies of water absorption and degradation—and in vivo studies—confirmed that the nanocomposite hydrogels described here are biodegradable, biocompatible, and facilitate apatite formation while immersed in the simulated body fluid (SBF). In light of these findings, the GA/Ch/nHA nanocomposite hydrogels are recommended for preparing bioactive nanoscaffolds for testing in bone regeneration applications. |
| first_indexed | 2024-03-09T12:15:29Z |
| format | Article |
| id | doaj.art-1247e704eafa4ee78170f14dd5144c56 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T12:15:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-1247e704eafa4ee78170f14dd5144c562023-11-30T22:46:38ZengMDPI AGPolymers2073-43602022-07-011415305210.3390/polym14153052Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone RegenerationLara E. Makar0Norhan Nady1Ahmed Abd El-Fattah2Neivin Shawky3Sherif H. Kandil4Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, El-Shatby, Alexandria 21526, EgyptPolymeric Materials Research Department, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, EgyptDepartment of Materials Science, Institute of Graduate Studies and Research, Alexandria University, El-Shatby, Alexandria 21526, EgyptOral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Champollion Street—Azarita, Alexandria 21526, EgyptDepartment of Materials Science, Institute of Graduate Studies and Research, Alexandria University, El-Shatby, Alexandria 21526, EgyptIn this work, physical cross-linking was used to create nanocomposite hydrogels composed of unmodified gum arabic (GA), chitosan (Ch), and natural nanohydroxyapatite (nHA), using an acrylic acid (AA) solvent. Different GA/chitosan contents (15%, 25%, and 35% of the used AA) as well as different nHA contents (2, 5, and 10 wt.%), were used and studied. The natural nHA and the fabricated GA/Ch/nHA nanocomposite hydrogels were characterized using different analysis techniques. Using acrylic acid solvent produced novel hydrogels with compressive strength of 15.43–22.20 MPa which is similar to that of natural cortical bone. The addition of natural nHA to the hydrogels resulted in a significant improvement in the compressive strength of the fabricated hydrogels. In vitro studies of water absorption and degradation—and in vivo studies—confirmed that the nanocomposite hydrogels described here are biodegradable, biocompatible, and facilitate apatite formation while immersed in the simulated body fluid (SBF). In light of these findings, the GA/Ch/nHA nanocomposite hydrogels are recommended for preparing bioactive nanoscaffolds for testing in bone regeneration applications.https://www.mdpi.com/2073-4360/14/15/3052hydrogelunmodified gum arabicchitosannatural nanohydroxyapatitecomposite scaffoldacrylic acid |
| spellingShingle | Lara E. Makar Norhan Nady Ahmed Abd El-Fattah Neivin Shawky Sherif H. Kandil Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration Polymers hydrogel unmodified gum arabic chitosan natural nanohydroxyapatite composite scaffold acrylic acid |
| title | Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration |
| title_full | Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration |
| title_fullStr | Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration |
| title_full_unstemmed | Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration |
| title_short | Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration |
| title_sort | unmodified gum arabic chitosan nanohydroxyapatite nanocomposite hydrogels as potential scaffolds for bone regeneration |
| topic | hydrogel unmodified gum arabic chitosan natural nanohydroxyapatite composite scaffold acrylic acid |
| url | https://www.mdpi.com/2073-4360/14/15/3052 |
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