Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression
Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and r...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=944;epage=950;aulast=Zhao |
| _version_ | 1818135446824157184 |
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| author | Yong-lin Zhao Jin-ning Song Xu-dong Ma Bin-fei Zhang Dan-dong Li Hong-gang Pang |
| author_facet | Yong-lin Zhao Jin-ning Song Xu-dong Ma Bin-fei Zhang Dan-dong Li Hong-gang Pang |
| author_sort | Yong-lin Zhao |
| collection | DOAJ |
| description | Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau (phosphorylated at Ser 404 (p-tau (S 404 )), and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau (S 404 ) levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury. |
| first_indexed | 2024-12-11T09:24:39Z |
| format | Article |
| id | doaj.art-124883527abb4db5ba1310e81021e882 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T09:24:39Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-124883527abb4db5ba1310e81021e8822022-12-22T01:13:10ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111694495010.4103/1673-5374.184493Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expressionYong-lin ZhaoJin-ning SongXu-dong MaBin-fei ZhangDan-dong LiHong-gang PangRosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau (phosphorylated at Ser 404 (p-tau (S 404 )), and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau (S 404 ) levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=944;epage=950;aulast=Zhaonerve regeneration; diffuse axonal injury; rosiglitazone; hyperphosphorylated tau; total tau; caveolin-1; rats; amyloid precursor protein; ser404; cortex; immunocytochemistry; western blot assay; neural regeneration |
| spellingShingle | Yong-lin Zhao Jin-ning Song Xu-dong Ma Bin-fei Zhang Dan-dong Li Hong-gang Pang Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression Neural Regeneration Research nerve regeneration; diffuse axonal injury; rosiglitazone; hyperphosphorylated tau; total tau; caveolin-1; rats; amyloid precursor protein; ser404; cortex; immunocytochemistry; western blot assay; neural regeneration |
| title | Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression |
| title_full | Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression |
| title_fullStr | Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression |
| title_full_unstemmed | Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression |
| title_short | Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression |
| title_sort | rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up regulating caveolin 1 expression |
| topic | nerve regeneration; diffuse axonal injury; rosiglitazone; hyperphosphorylated tau; total tau; caveolin-1; rats; amyloid precursor protein; ser404; cortex; immunocytochemistry; western blot assay; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=944;epage=950;aulast=Zhao |
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