Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression

Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression

Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and r...

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Bibliographic Details
Main Authors: Yong-lin Zhao, Jin-ning Song, Xu-dong Ma, Bin-fei Zhang, Dan-dong Li, Hong-gang Pang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; diffuse axonal injury; rosiglitazone; hyperphosphorylated tau; total tau; caveolin-1; rats; amyloid precursor protein; ser404; cortex; immunocytochemistry; western blot assay; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=944;epage=950;aulast=Zhao

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