Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations]
Background: Childhood cancer is considered one the most important causes of death in children and adolescents, despite having a low incidence in this population. Spatial analysis has been previously used for the study of childhood cancer to study the geographical distribution of leukemias. This stud...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-06-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/10-86/v2 |
| _version_ | 1819071321437372416 |
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| author | Edgar F. Manrique-Hernández Marcela Pilar Rojas Díaz Laura Andrea Rodriguez-Villamizar |
| author_facet | Edgar F. Manrique-Hernández Marcela Pilar Rojas Díaz Laura Andrea Rodriguez-Villamizar |
| author_sort | Edgar F. Manrique-Hernández |
| collection | DOAJ |
| description | Background: Childhood cancer is considered one the most important causes of death in children and adolescents, despite having a low incidence in this population. Spatial analysis has been previously used for the study of childhood cancer to study the geographical distribution of leukemias. This study aimed to identify the presence of space-time clusters of childhood of cancer excluding leukemia in Colombia between 2014 and 2017. Methods: All incident cancer cases (excluding leukemia) in children under the age of 15 years that had been confirmed by the National Surveillance System of Childhood Cancer between 2014 and 2017 were included. Kulldorf’s circular scan test was used to identify clusters using the municipality of residence as the spatial unit of analysis and the year of diagnosis as the temporal unit of analysis. A sensitivity analysis was conducted with different upper limit parameters for the at-risk population in the clusters. Results: A total of 2006 cases of non-leukemia childhood cancer were analyzed, distributed in 432 out of 1,122 municipalities with a mean annual incidence rate of 44 cases per million children under the age of 15. Central nervous system (CNS) tumors were the most frequent type. Two space-time clusters were identified in the central and southwest regions of the country. In the analysis for CNS tumors, a spatial cluster was identified in the central region of the country. Conclusions: The distribution of non-leukemia childhood cancer seems to have a clustered distribution in some Colombian regions that may suggest infectious or environmental factors associated with its incidence although heterogeneity in access to diagnosis cannot be discarded. |
| first_indexed | 2024-12-21T17:19:58Z |
| format | Article |
| id | doaj.art-12491e081e90415b9283d51b1e57be3b |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T17:19:58Z |
| publishDate | 2021-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-12491e081e90415b9283d51b1e57be3b2022-12-21T18:56:12ZengF1000 Research LtdF1000Research2046-14022021-06-011010.12688/f1000research.27766.257186Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations]Edgar F. Manrique-Hernández0Marcela Pilar Rojas Díaz1Laura Andrea Rodriguez-Villamizar2Public Health Department, School of Medicine, Universidad Industrial de Santander. Bucaramanga, Santander, ColombiaInstituto Nacional de Salud, Bogotá D.C., ColombiaPublic Health Department, School of Medicine, Universidad Industrial de Santander. Bucaramanga, Santander, ColombiaBackground: Childhood cancer is considered one the most important causes of death in children and adolescents, despite having a low incidence in this population. Spatial analysis has been previously used for the study of childhood cancer to study the geographical distribution of leukemias. This study aimed to identify the presence of space-time clusters of childhood of cancer excluding leukemia in Colombia between 2014 and 2017. Methods: All incident cancer cases (excluding leukemia) in children under the age of 15 years that had been confirmed by the National Surveillance System of Childhood Cancer between 2014 and 2017 were included. Kulldorf’s circular scan test was used to identify clusters using the municipality of residence as the spatial unit of analysis and the year of diagnosis as the temporal unit of analysis. A sensitivity analysis was conducted with different upper limit parameters for the at-risk population in the clusters. Results: A total of 2006 cases of non-leukemia childhood cancer were analyzed, distributed in 432 out of 1,122 municipalities with a mean annual incidence rate of 44 cases per million children under the age of 15. Central nervous system (CNS) tumors were the most frequent type. Two space-time clusters were identified in the central and southwest regions of the country. In the analysis for CNS tumors, a spatial cluster was identified in the central region of the country. Conclusions: The distribution of non-leukemia childhood cancer seems to have a clustered distribution in some Colombian regions that may suggest infectious or environmental factors associated with its incidence although heterogeneity in access to diagnosis cannot be discarded.https://f1000research.com/articles/10-86/v2 |
| spellingShingle | Edgar F. Manrique-Hernández Marcela Pilar Rojas Díaz Laura Andrea Rodriguez-Villamizar Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] F1000Research |
| title | Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_full | Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_fullStr | Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_full_unstemmed | Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_short | Clustering of non-leukemia childhood cancer in Colombia: a nationwide study [version 2; peer review: 2 approved, 2 approved with reservations] |
| title_sort | clustering of non leukemia childhood cancer in colombia a nationwide study version 2 peer review 2 approved 2 approved with reservations |
| url | https://f1000research.com/articles/10-86/v2 |
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