The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential
Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow down the progression of pulmonary fibrosis, they are unable...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273248/full |
| _version_ | 1797650027486642176 |
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| author | Jing Zhang Jing Zhang Lanlan Zhang Yutian Chen Xiaobin Fang Bo Li Chunheng Mo |
| author_facet | Jing Zhang Jing Zhang Lanlan Zhang Yutian Chen Xiaobin Fang Bo Li Chunheng Mo |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow down the progression of pulmonary fibrosis, they are unable to reverse the disease. Therefore, there is an urgent demand to develop more efficient therapeutic approaches for pulmonary fibrosis. The intracellular DNA sensor called cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) plays a crucial role in detecting DNA and generating cGAMP, a second messenger. Subsequently, cGAMP triggers the activation of stimulator of interferon genes (STING), initiating a signaling cascade that leads to the stimulation of type I interferons and other signaling molecules involved in immune responses. Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This review aims to provide a comprehensive summary of the current knowledge regarding the role of cGAS-STING pathway in pulmonary fibrosis. Moreover, we discuss the potential therapeutic implications of targeting the cGAS-STING pathway, including the utilization of inhibitors of cGAS and STING. |
| first_indexed | 2024-03-11T15:55:36Z |
| format | Article |
| id | doaj.art-124a026d817b4431bd5105def4753988 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T15:55:36Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-124a026d817b4431bd5105def47539882023-10-25T11:06:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12732481273248The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potentialJing Zhang0Jing Zhang1Lanlan Zhang2Yutian Chen3Xiaobin Fang4Bo Li5Chunheng Mo6Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, ChinaSchool of Basic Medicine, Jining Medical University, Jining, Shandong, ChinaState Key Laboratory of Respiratory Health and Multimorbidity, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaThe Department of Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaFujian Provincial Key Laboratory of Critical Care Medicine, Department of Anesthesiology/Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, ChinaPulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow down the progression of pulmonary fibrosis, they are unable to reverse the disease. Therefore, there is an urgent demand to develop more efficient therapeutic approaches for pulmonary fibrosis. The intracellular DNA sensor called cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) plays a crucial role in detecting DNA and generating cGAMP, a second messenger. Subsequently, cGAMP triggers the activation of stimulator of interferon genes (STING), initiating a signaling cascade that leads to the stimulation of type I interferons and other signaling molecules involved in immune responses. Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This review aims to provide a comprehensive summary of the current knowledge regarding the role of cGAS-STING pathway in pulmonary fibrosis. Moreover, we discuss the potential therapeutic implications of targeting the cGAS-STING pathway, including the utilization of inhibitors of cGAS and STING.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273248/fullpulmonary fibrosiscGAS-STINGsignaling pathwayinhibitorstherapeutic potential |
| spellingShingle | Jing Zhang Jing Zhang Lanlan Zhang Yutian Chen Xiaobin Fang Bo Li Chunheng Mo The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential Frontiers in Immunology pulmonary fibrosis cGAS-STING signaling pathway inhibitors therapeutic potential |
| title | The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential |
| title_full | The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential |
| title_fullStr | The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential |
| title_full_unstemmed | The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential |
| title_short | The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential |
| title_sort | role of cgas sting signaling in pulmonary fibrosis and its therapeutic potential |
| topic | pulmonary fibrosis cGAS-STING signaling pathway inhibitors therapeutic potential |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273248/full |
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