The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer
Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in40 cases of PC, 8 cases of nodular hyperplas...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2017-08-01
|
| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4754 |
| _version_ | 1818138027976818688 |
|---|---|
| author | I. I. Yakovtcova P. V. Tkachenko I. V. Ivakhno |
| author_facet | I. I. Yakovtcova P. V. Tkachenko I. V. Ivakhno |
| author_sort | I. I. Yakovtcova |
| collection | DOAJ |
| description | Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease. |
| first_indexed | 2024-12-11T10:05:40Z |
| format | Article |
| id | doaj.art-124a4e2d80134b94a6b99ba0a43b12a6 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-11T10:05:40Z |
| publishDate | 2017-08-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-124a4e2d80134b94a6b99ba0a43b12a62022-12-22T01:11:57ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-08-017841542210.5281/zenodo.8525704485The significance of angiogenesis in tumorigenesis and prognosis of prostate cancerI. I. Yakovtcova0P. V. Tkachenko1I. V. Ivakhno2Kharkiv medical academy of postgraduate educationKharkiv medical academy of postgraduate educationKharkiv medical academy of postgraduate educationAngiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4754prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density. |
| spellingShingle | I. I. Yakovtcova P. V. Tkachenko I. V. Ivakhno The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer Journal of Education, Health and Sport prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density. |
| title | The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| title_full | The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| title_fullStr | The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| title_full_unstemmed | The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| title_short | The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| title_sort | significance of angiogenesis in tumorigenesis and prognosis of prostate cancer |
| topic | prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density. |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4754 |
| work_keys_str_mv | AT iiyakovtcova thesignificanceofangiogenesisintumorigenesisandprognosisofprostatecancer AT pvtkachenko thesignificanceofangiogenesisintumorigenesisandprognosisofprostatecancer AT ivivakhno thesignificanceofangiogenesisintumorigenesisandprognosisofprostatecancer AT iiyakovtcova significanceofangiogenesisintumorigenesisandprognosisofprostatecancer AT pvtkachenko significanceofangiogenesisintumorigenesisandprognosisofprostatecancer AT ivivakhno significanceofangiogenesisintumorigenesisandprognosisofprostatecancer |