Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan
The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolut...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2016-02-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-2&slc_lang=en&sid=1 |
| _version_ | 1818852243293601792 |
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| author | Syed Faisal Ali Monika Joshi Nida Akhtar Vijay Sharma Kamla Pathak |
| author_facet | Syed Faisal Ali Monika Joshi Nida Akhtar Vijay Sharma Kamla Pathak |
| author_sort | Syed Faisal Ali |
| collection | DOAJ |
| description | The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68, Gelucire 50/13 and Plasdone S630. A total of nine batches (SD1-SD9) were characterized for micromeritic properties, in vitro dissolution behavior and surface characterization. SD4 with 52.43% cumulative drug release (CDR) in phosphate buffer, pH 7.4, in 120 min, t50% 44.2 min and DE30min 96.76% was selected for the development of semi-solid capsules. Differential scanning calorimetry of SD4 revealed molecular dispersion of TLMS in Pluronic-F68. SD4 was formulated into SSCs using Gelucire 44/14 and PEG 400 as semi-solid components and PEG 6000 as a suspending agent to achieve reduction in lag time for effective drug dissolution. SSC6 showed maximum in vitro drug dissolution 97.49 % in phosphate buffer, pH 7.4 with in 20 min that was almost a three folds reduction in the time required to achieve similar dissolution by SD. Thus, SSCs present an excellent approach to enhance in vitro dissolution as well as to reduce the lag time of dissolution for poorly water soluble drugs especially to those therapeutic classes that are intended for faster onset of action. Developed approach based on HPMC capsules provided a better alternative to target delivery of telmisartan to the vegetarian population. |
| first_indexed | 2024-12-19T07:17:49Z |
| format | Article |
| id | doaj.art-124a7e3ceb254bfdb94eb9a8bf09e05a |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-19T07:17:49Z |
| publishDate | 2016-02-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-124a7e3ceb254bfdb94eb9a8bf09e05a2022-12-21T20:31:01ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942016-02-01212335Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartanSyed Faisal Ali0Monika Joshi1Nida Akhtar2Vijay Sharma3Kamla Pathak4 Department of Pharmaceutics, Pharmacy College Saifai, Saifai, Etawah, Uttar Pradesh, India Department of Pharmaceutics, Pharmacy College Saifai, Saifai, Etawah, Uttar Pradesh, India Department of Pharmaceutics, Pharmacy College Saifai, Saifai, Etawah, Uttar Pradesh, India Department of Pharmaceutics, Pharmacy College Saifai, Saifai, Etawah, Uttar Pradesh, India Department of Pharmaceutics, Pharmacy College Saifai, Saifai, Etawah, Uttar Pradesh, India The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68, Gelucire 50/13 and Plasdone S630. A total of nine batches (SD1-SD9) were characterized for micromeritic properties, in vitro dissolution behavior and surface characterization. SD4 with 52.43% cumulative drug release (CDR) in phosphate buffer, pH 7.4, in 120 min, t50% 44.2 min and DE30min 96.76% was selected for the development of semi-solid capsules. Differential scanning calorimetry of SD4 revealed molecular dispersion of TLMS in Pluronic-F68. SD4 was formulated into SSCs using Gelucire 44/14 and PEG 400 as semi-solid components and PEG 6000 as a suspending agent to achieve reduction in lag time for effective drug dissolution. SSC6 showed maximum in vitro drug dissolution 97.49 % in phosphate buffer, pH 7.4 with in 20 min that was almost a three folds reduction in the time required to achieve similar dissolution by SD. Thus, SSCs present an excellent approach to enhance in vitro dissolution as well as to reduce the lag time of dissolution for poorly water soluble drugs especially to those therapeutic classes that are intended for faster onset of action. Developed approach based on HPMC capsules provided a better alternative to target delivery of telmisartan to the vegetarian population.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-2&slc_lang=en&sid=1in vitro dissolution lag time HPMC capsules solid dispersion solubility |
| spellingShingle | Syed Faisal Ali Monika Joshi Nida Akhtar Vijay Sharma Kamla Pathak Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan Pharmaceutical and Biomedical Research in vitro dissolution lag time HPMC capsules solid dispersion solubility |
| title | Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan |
| title_full | Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan |
| title_fullStr | Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan |
| title_full_unstemmed | Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan |
| title_short | Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan |
| title_sort | combinational approach using solid dispersion and semi solid matrix technology to enhance in vitro dissolution of telmisartan |
| topic | in vitro dissolution lag time HPMC capsules solid dispersion solubility |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-53-2&slc_lang=en&sid=1 |
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