Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Abstract Background Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymp...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12979-023-00370-8 |
| _version_ | 1797451452295151616 |
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| author | Raffaello Pellegrino Roberto Paganelli Angelo Di Iorio Stefania Bandinelli Antimo Moretti Giovanni Iolascon Eleonora Sparvieri Domiziano Tarantino Luigi Ferrucci |
| author_facet | Raffaello Pellegrino Roberto Paganelli Angelo Di Iorio Stefania Bandinelli Antimo Moretti Giovanni Iolascon Eleonora Sparvieri Domiziano Tarantino Luigi Ferrucci |
| author_sort | Raffaello Pellegrino |
| collection | DOAJ |
| description | Abstract Background Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymphocytes-ratio (NL-ratio) was proposed as an effective and low-cost marker to monitor and predict the evolution of several clinical conditions. The main objective of the study is to analyze its temporal trend variation, over twenty years’ follow-up, according to age, sex, and main clinical diagnosis, in a large representative Italian population. Methods The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998, and last follow-up visits were made in 2015-18. 1343 out of the 1453 participants enrolled were included, and consented to donate a blood sample. All subjects were assessed and followed for life-style, clinical condition, physical performance, and underwent an instrumental diagnostic session. Results The NL-ratio showed a statistically significant interaction between birth-cohort and time of the study (p-value = 0.005). A gender dimorphism was recognized in the neutrophils absolute count and in the NL-ratio. Moreover, in female participants only, those who reported CHF had lower neutrophil-count and NL-ratio; whereas an increase in creatinine clearance was directly associated with NL-ratio. In male subjects, an increase of BMI was inversely associated with both NL-ratio and neutrophils-count during the follow-up; a similar association but in the opposite direction was observed in female participants. Conclusion NL-ratio is a more reliable predictor of healthy aging than absolute lymphocytes and/or neutrophils counts. It is associated with the changes induced by disease, lifestyle, and environmental challenges in the immune system. NL-ratio confirms the gender dimorphism in the occurrence of inflammation-driven diseases, thus providing additional evidence for the necessity of tailored sex-specific measures to prevent and treat such diseases. |
| first_indexed | 2024-03-09T14:54:51Z |
| format | Article |
| id | doaj.art-124b0258eda94dde94c067682dc43c0b |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-03-09T14:54:51Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-124b0258eda94dde94c067682dc43c0b2023-11-26T14:14:01ZengBMCImmunity & Ageing1742-49332023-09-0120111010.1186/s12979-023-00370-8Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up studyRaffaello Pellegrino0Roberto Paganelli1Angelo Di Iorio2Stefania Bandinelli3Antimo Moretti4Giovanni Iolascon5Eleonora Sparvieri6Domiziano Tarantino7Luigi Ferrucci8Department of Scientific Research, Off-Campus Semmelweis UniversitySaint Camillus International University of Health and Medical SciencesDepartment of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio”Geriatric Unit, Azienda Toscana CentroDepartment of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”Department of Internal Medicine, ASL TeramoDepartment of Public Health, University of Naples Federico IILongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of HealthAbstract Background Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymphocytes-ratio (NL-ratio) was proposed as an effective and low-cost marker to monitor and predict the evolution of several clinical conditions. The main objective of the study is to analyze its temporal trend variation, over twenty years’ follow-up, according to age, sex, and main clinical diagnosis, in a large representative Italian population. Methods The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998, and last follow-up visits were made in 2015-18. 1343 out of the 1453 participants enrolled were included, and consented to donate a blood sample. All subjects were assessed and followed for life-style, clinical condition, physical performance, and underwent an instrumental diagnostic session. Results The NL-ratio showed a statistically significant interaction between birth-cohort and time of the study (p-value = 0.005). A gender dimorphism was recognized in the neutrophils absolute count and in the NL-ratio. Moreover, in female participants only, those who reported CHF had lower neutrophil-count and NL-ratio; whereas an increase in creatinine clearance was directly associated with NL-ratio. In male subjects, an increase of BMI was inversely associated with both NL-ratio and neutrophils-count during the follow-up; a similar association but in the opposite direction was observed in female participants. Conclusion NL-ratio is a more reliable predictor of healthy aging than absolute lymphocytes and/or neutrophils counts. It is associated with the changes induced by disease, lifestyle, and environmental challenges in the immune system. NL-ratio confirms the gender dimorphism in the occurrence of inflammation-driven diseases, thus providing additional evidence for the necessity of tailored sex-specific measures to prevent and treat such diseases.https://doi.org/10.1186/s12979-023-00370-8NeutrophilsLymphocytesNeutrophils-to-Lymphocytes-ratioObservational studyLongitudinal studyTemporal-trends |
| spellingShingle | Raffaello Pellegrino Roberto Paganelli Angelo Di Iorio Stefania Bandinelli Antimo Moretti Giovanni Iolascon Eleonora Sparvieri Domiziano Tarantino Luigi Ferrucci Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study Immunity & Ageing Neutrophils Lymphocytes Neutrophils-to-Lymphocytes-ratio Observational study Longitudinal study Temporal-trends |
| title | Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study |
| title_full | Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study |
| title_fullStr | Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study |
| title_full_unstemmed | Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study |
| title_short | Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study |
| title_sort | temporal trends sex differences and age related disease influence in neutrophil lymphocyte count and neutrophil to lymphocyte ratio results from inchianti follow up study |
| topic | Neutrophils Lymphocytes Neutrophils-to-Lymphocytes-ratio Observational study Longitudinal study Temporal-trends |
| url | https://doi.org/10.1186/s12979-023-00370-8 |
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