Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology
The Cryo-EM structures reported in this work reveal how heparin incorporates into α-syn fibril formation to determine fibril polymorphs. This highlights the role of biological polymers in the conformational selection and neuropathological regulation of amyloid fibrils.
Bibliographic Details
| Main Authors: |
Youqi Tao,
Yunpeng Sun,
Shiran Lv,
Wencheng Xia,
Kun Zhao,
Qianhui Xu,
Qinyue Zhao,
Lin He,
Weidong Le,
Yong Wang,
Cong Liu,
Dan Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31790-7
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