Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer
Yu Cao,1,* Huajian Zhu,1,* Ruoyu He,2 Limin Kong,3 Jiaan Shao,1 Rangxiao Zhuang,2 Jianjun Xi,2 Jiankang Zhang1 1School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province, 310015, People’s Republic of China; 2Department of Pharmaceutical Preparation, Hangzhou Xixi Ho...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-10-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://test.dovepress.com/proteasome-a-promising-therapeutic-target-for-multiple-diseases-beyond-peer-reviewed-article-DDDT |
| _version_ | 1818883190421454848 |
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| author | Cao Y Zhu H He R Kong L Shao J Zhuang R Xi J Zhang J |
| author_facet | Cao Y Zhu H He R Kong L Shao J Zhuang R Xi J Zhang J |
| author_sort | Cao Y |
| collection | DOAJ |
| description | Yu Cao,1,* Huajian Zhu,1,* Ruoyu He,2 Limin Kong,3 Jiaan Shao,1 Rangxiao Zhuang,2 Jianjun Xi,2 Jiankang Zhang1 1School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province, 310015, People’s Republic of China; 2Department of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, 310023 People’s Republic of China; 3Department of Pharmacy, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianjun XiDepartment of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province 310023, People’s Republic of ChinaEmail xjianjun@foxmail.comJiankang ZhangSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province 310015, People’s Republic of ChinaEmail zjk0125@yeah.netAbstract : Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized.Keywords: proteasome inhibitor, infectious diseases, autoimmune diseases, neurodegenerative diseases, drugs |
| first_indexed | 2024-12-19T15:29:43Z |
| format | Article |
| id | doaj.art-124c9cd178d6476dab7f6e9e818a83e5 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-19T15:29:43Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-124c9cd178d6476dab7f6e9e818a83e52022-12-21T20:15:46ZengDove Medical PressDrug Design, Development and Therapy1177-88812020-10-01Volume 144327434258238Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond CancerCao YZhu HHe RKong LShao JZhuang RXi JZhang JYu Cao,1,* Huajian Zhu,1,* Ruoyu He,2 Limin Kong,3 Jiaan Shao,1 Rangxiao Zhuang,2 Jianjun Xi,2 Jiankang Zhang1 1School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province, 310015, People’s Republic of China; 2Department of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province, 310023 People’s Republic of China; 3Department of Pharmacy, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianjun XiDepartment of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou, Zhejiang Province 310023, People’s Republic of ChinaEmail xjianjun@foxmail.comJiankang ZhangSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang Province 310015, People’s Republic of ChinaEmail zjk0125@yeah.netAbstract : Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized.Keywords: proteasome inhibitor, infectious diseases, autoimmune diseases, neurodegenerative diseases, drugshttps://test.dovepress.com/proteasome-a-promising-therapeutic-target-for-multiple-diseases-beyond-peer-reviewed-article-DDDTproteasome inhibitorinfectious diseasesautoimmune diseasesneurodegenerative diseasesdrugs |
| spellingShingle | Cao Y Zhu H He R Kong L Shao J Zhuang R Xi J Zhang J Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer Drug Design, Development and Therapy proteasome inhibitor infectious diseases autoimmune diseases neurodegenerative diseases drugs |
| title | Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer |
| title_full | Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer |
| title_fullStr | Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer |
| title_full_unstemmed | Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer |
| title_short | Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer |
| title_sort | proteasome a promising therapeutic target for multiple diseases beyond cancer |
| topic | proteasome inhibitor infectious diseases autoimmune diseases neurodegenerative diseases drugs |
| url | https://test.dovepress.com/proteasome-a-promising-therapeutic-target-for-multiple-diseases-beyond-peer-reviewed-article-DDDT |
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