Vaccines to prevent Ebola virus disease: current challenges and perspectives
Relevance. Ebola virus disease (EVD) is an acute infectious disease with an extremely high case fatality rate reaching up to 90%. EVD has become widely known since 20142016, when outbreak in West Africa occurred and led to epidemic, which caused travel-related cases on the territory of other contine...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2023-11-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/15681/808 |
| _version_ | 1797550207979749376 |
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| author | Anna V. Kovyrshina Tatiana E. Sizikova Vitaliy N. Lebedev Sergey V. Borisevich Inna V. Dolzhikova Denis Yu. Logunov Alexander L. Gintsburg |
| author_facet | Anna V. Kovyrshina Tatiana E. Sizikova Vitaliy N. Lebedev Sergey V. Borisevich Inna V. Dolzhikova Denis Yu. Logunov Alexander L. Gintsburg |
| author_sort | Anna V. Kovyrshina |
| collection | DOAJ |
| description | Relevance. Ebola virus disease (EVD) is an acute infectious disease with an extremely high case fatality rate reaching up to 90%. EVD has become widely known since 20142016, when outbreak in West Africa occurred and led to epidemic, which caused travel-related cases on the territory of other continents.
There are two vaccines against EVD, prequalified by WHO for emergency use, as well as a number of vaccines, approved by local regulators in certain countries. However, even with the availability of effective vaccines, the lack of data on immune correlates of protection and duration of protective immune response in humans and primates is limiting factor for effectively preventing the spread of EVD outbreaks.
Aims. This review highlights experience of use of EVD vaccines during outbreaks in endemic areas, summarizes data on vaccine immunogenicity in clinical trials, and discusses perspectives for further development and use of effective EVD vaccines. |
| first_indexed | 2024-03-10T15:25:17Z |
| format | Article |
| id | doaj.art-124f2f414d00433b840230a982b12f9a |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-10T15:25:17Z |
| publishDate | 2023-11-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-124f2f414d00433b840230a982b12f9a2023-11-20T18:03:21ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972023-11-0168537238410.36233/0507-4088-1931183Vaccines to prevent Ebola virus disease: current challenges and perspectivesAnna V. Kovyrshina0https://orcid.org/0000-0002-8757-7026Tatiana E. Sizikova1https://orcid.org/0000-0002-1817-0126Vitaliy N. Lebedev2https://orcid.org/0000-0002-6552-4599Sergey V. Borisevich3https://orcid.org/0000-0002-6742-3919Inna V. Dolzhikova4https://orcid.org/0000-0003-2548-6142Denis Yu. Logunov5https://orcid.org/0000-0003-4035-6581Alexander L. Gintsburg6https://orcid.org/0000-0003-1769-5059National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation48 Central Scientific Research Institute of the Ministry of Defence of the Russian Federation48 Central Scientific Research Institute of the Ministry of Defence of the Russian Federation48 Central Scientific Research Institute of the Ministry of Defence of the Russian FederationNational Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian FederationNational Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian FederationNational Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian FederationRelevance. Ebola virus disease (EVD) is an acute infectious disease with an extremely high case fatality rate reaching up to 90%. EVD has become widely known since 20142016, when outbreak in West Africa occurred and led to epidemic, which caused travel-related cases on the territory of other continents. There are two vaccines against EVD, prequalified by WHO for emergency use, as well as a number of vaccines, approved by local regulators in certain countries. However, even with the availability of effective vaccines, the lack of data on immune correlates of protection and duration of protective immune response in humans and primates is limiting factor for effectively preventing the spread of EVD outbreaks. Aims. This review highlights experience of use of EVD vaccines during outbreaks in endemic areas, summarizes data on vaccine immunogenicity in clinical trials, and discusses perspectives for further development and use of effective EVD vaccines.https://virusjour.crie.ru/jour/article/viewFile/15681/808ebola virus diseaseviral vector vaccinedna vaccineclinical trials |
| spellingShingle | Anna V. Kovyrshina Tatiana E. Sizikova Vitaliy N. Lebedev Sergey V. Borisevich Inna V. Dolzhikova Denis Yu. Logunov Alexander L. Gintsburg Vaccines to prevent Ebola virus disease: current challenges and perspectives Вопросы вирусологии ebola virus disease viral vector vaccine dna vaccine clinical trials |
| title | Vaccines to prevent Ebola virus disease: current challenges and perspectives |
| title_full | Vaccines to prevent Ebola virus disease: current challenges and perspectives |
| title_fullStr | Vaccines to prevent Ebola virus disease: current challenges and perspectives |
| title_full_unstemmed | Vaccines to prevent Ebola virus disease: current challenges and perspectives |
| title_short | Vaccines to prevent Ebola virus disease: current challenges and perspectives |
| title_sort | vaccines to prevent ebola virus disease current challenges and perspectives |
| topic | ebola virus disease viral vector vaccine dna vaccine clinical trials |
| url | https://virusjour.crie.ru/jour/article/viewFile/15681/808 |
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