Hepatotoxicity and Langerhans Islets Regenerative Effects of Polar and Neutral Lipids of Nigella sativa L. in Nicotinamide/streptozotocin-Induced Diabetic Rats
The extracted oil from Nigella sativa seeds is reported to be effective against various diseases and chemicallyinduced hepatotoxicity and nephrotoxicity. The effect of oral administration of Nigella sativa total, polar and neutral oils was investigated on hepatoprotective status in streptozotocin/ni...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2011-02-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.2011.22.1.97 |
| Summary: | The extracted oil from Nigella sativa seeds is reported to be effective against various diseases and chemicallyinduced hepatotoxicity and nephrotoxicity. The effect of oral administration of Nigella sativa total, polar and neutral oils was investigated on hepatoprotective status in streptozotocin/nicotinamide (STZ-N)-induced diabetic rats. The toxicity was assessed biochemically by monitoring aspartate transaminase (AST), alanine transaminase (ALT), gamma-glutamyl transpeptitase (g-GT) and alkaline phosphatase (AP) activities as well as biluribin titre and histologically under light microscope. The study was also undertaken to evaluate the effect of oil fractions on the regeneration of pancreatic Langerhans islets in treated diabetic rats. |
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| ISSN: | 0933-4807 2195-4720 |