The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics
The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/737 |
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| author | Artem Piddubnyi Olena Kolomiiets Sergey Danilchenko Andriy Stepanenko Yuliia Moskalenko Roman Moskalenko |
| author_facet | Artem Piddubnyi Olena Kolomiiets Sergey Danilchenko Andriy Stepanenko Yuliia Moskalenko Roman Moskalenko |
| author_sort | Artem Piddubnyi |
| collection | DOAJ |
| description | The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications. The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher expression of osteopontin in the calcified breast cancer samples (<i>p</i> ˂ 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocalization of oxalate microcalcifications together with biominerals of the usual “hydroxyapatite” phase composition. The simultaneous presence of calcium oxalate and hydroxyapatite was accompanied by a different spatial localization of microcalcifications. Thus, the phase compositions of microcalcifications could not be used as criteria for the differential diagnostics of breast tumors. |
| first_indexed | 2024-03-11T08:56:34Z |
| format | Article |
| id | doaj.art-12515ced9a4442ae954d3b61be48c200 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:56:34Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-12515ced9a4442ae954d3b61be48c2002023-11-16T20:02:15ZengMDPI AGDiagnostics2075-44182023-02-0113473710.3390/diagnostics13040737The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer DiagnosticsArtem Piddubnyi0Olena Kolomiiets1Sergey Danilchenko2Andriy Stepanenko3Yuliia Moskalenko4Roman Moskalenko5Department of Pathology, Sumy State University, 40022 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkraineInstitute of Applied Physics, NAS of Ukraine, 40007 Sumy, UkraineDepartment of Electronics, General and Applied Physics, Sumy State University, 40007 Sumy, UkraineDepartment of Oncology and Radiology, Sumy State University, 40022 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkraineThe detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications. The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher expression of osteopontin in the calcified breast cancer samples (<i>p</i> ˂ 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocalization of oxalate microcalcifications together with biominerals of the usual “hydroxyapatite” phase composition. The simultaneous presence of calcium oxalate and hydroxyapatite was accompanied by a different spatial localization of microcalcifications. Thus, the phase compositions of microcalcifications could not be used as criteria for the differential diagnostics of breast tumors.https://www.mdpi.com/2075-4418/13/4/737breast cancermicrocalcificationphase analysis |
| spellingShingle | Artem Piddubnyi Olena Kolomiiets Sergey Danilchenko Andriy Stepanenko Yuliia Moskalenko Roman Moskalenko The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics Diagnostics breast cancer microcalcification phase analysis |
| title | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
| title_full | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
| title_fullStr | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
| title_full_unstemmed | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
| title_short | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
| title_sort | prospects of using structural phase analysis of microcalcifications in breast cancer diagnostics |
| topic | breast cancer microcalcification phase analysis |
| url | https://www.mdpi.com/2075-4418/13/4/737 |
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