Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study
Abstract Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-020-00581-w |
| _version_ | 1818335266098642944 |
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| author | Takuro Okamura Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui |
| author_facet | Takuro Okamura Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui |
| author_sort | Takuro Okamura |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC. Results During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00–1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637–737, sensitivity = 0.620, specificity = 0.668, p < 0.001)). Conclusions TyG index can predict the onset of CRC. For early detection of CRC, we should encourage people with high TyG index to undergo screening for CRC. |
| first_indexed | 2024-12-13T14:20:41Z |
| format | Article |
| id | doaj.art-12532de08a6b40e1ac638d2c1fbc69c4 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-13T14:20:41Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-12532de08a6b40e1ac638d2c1fbc69c42022-12-21T23:42:05ZengBMCBMC Endocrine Disorders1472-68232020-07-012011710.1186/s12902-020-00581-wTriglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal studyTakuro Okamura0Yoshitaka Hashimoto1Masahide Hamaguchi2Akihiro Obora3Takao Kojima4Michiaki Fukui5Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceDepartment of Gastroenterology, Asahi University HospitalDepartment of Gastroenterology, Asahi University HospitalDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical ScienceAbstract Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC. Results During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00–1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637–737, sensitivity = 0.620, specificity = 0.668, p < 0.001)). Conclusions TyG index can predict the onset of CRC. For early detection of CRC, we should encourage people with high TyG index to undergo screening for CRC.http://link.springer.com/article/10.1186/s12902-020-00581-wCohort studyColorectal cancerTyG indexInsulin resistanceEpidemiology |
| spellingShingle | Takuro Okamura Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study BMC Endocrine Disorders Cohort study Colorectal cancer TyG index Insulin resistance Epidemiology |
| title | Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_full | Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_fullStr | Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_full_unstemmed | Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_short | Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study |
| title_sort | triglyceride glucose index tyg index is a predictor of incident colorectal cancer a population based longitudinal study |
| topic | Cohort study Colorectal cancer TyG index Insulin resistance Epidemiology |
| url | http://link.springer.com/article/10.1186/s12902-020-00581-w |
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