Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed
Systemic vaccination with the BNT162b2 mRNA vaccine stimulates the humoral response. Our study aimed to compare the intensity of the humoral immune response, measured by SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing IgG antibody levels after COVID-19 vaccination versus after SARS-CoV-2 infe...
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MDPI AG
2022-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/2/334 |
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| author | Piotr Kosiorek Dorota Elżbieta Kazberuk Anna Hryniewicz Robert Milewski Samuel Stróż Anna Stasiak-Barmuta |
| author_facet | Piotr Kosiorek Dorota Elżbieta Kazberuk Anna Hryniewicz Robert Milewski Samuel Stróż Anna Stasiak-Barmuta |
| author_sort | Piotr Kosiorek |
| collection | DOAJ |
| description | Systemic vaccination with the BNT162b2 mRNA vaccine stimulates the humoral response. Our study aimed to compare the intensity of the humoral immune response, measured by SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing IgG antibody levels after COVID-19 vaccination versus after SARS-CoV-2 infection. We analyzed 1060 people in the following groups: convalescents; healthy unvaccinated individuals; individuals vaccinated with Comirnaty, AstraZeneca, Moderna, or Johnson & Johnson; and vaccinated SARS-CoV-2 convalescents. The concentrations of SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing antibodies were estimated in an oncology hospital laboratory by chemiluminescent immunoassay (CLIA; MAGLUMI). Results: (1) We observed a rise in antibody response in both the SARS-CoV-2 convalescent and COVID-19-vaccinated groups. (2) The levels of all antibody concentrations in vaccinated COVID-19 convalescents were significantly higher. (3) We differentiated asymptomatic SARS-CoV-2 convalescents from the control group. Our analysis suggests that monitoring SARS-CoV-2 IgG antibody concentrations is essential as an indicator of asymptomatic COVID-19 and as a measure of the effectiveness of the humoral response in convalescents and vaccinated people. Considering the time-limited effects of post-SARS-CoV-2 infection recovery or vaccination and the physiological half-life, among other factors, we suggest monitoring IgG antibody levels as a criterion for future vaccination. |
| first_indexed | 2024-03-09T20:53:12Z |
| format | Article |
| id | doaj.art-12535a3abd5b4fb4aeeb5884855a8e0e |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T20:53:12Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-12535a3abd5b4fb4aeeb5884855a8e0e2023-11-23T22:27:24ZengMDPI AGVaccines2076-393X2022-02-0110233410.3390/vaccines10020334Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are NeededPiotr Kosiorek0Dorota Elżbieta Kazberuk1Anna Hryniewicz2Robert Milewski3Samuel Stróż4Anna Stasiak-Barmuta5Department of Emergency, Maria Sklodowska-Curie Bialystok Oncology Centre, Ogrodowa 12, 15-027 Białystok, PolandDepartment of Radiotherapy, Maria Sklodowska-Curie Bialystok Oncology Centre, Ogrodowa 12, 15-027 Białystok, PolandDepartment of Rehabilitation, Medical University of Białystok, Jana Kilińskiego 1, 15-089 Białystok, PolandDepartment of Statistics and Medical Informatics, Medical University of Białystok, Jana Kilińskiego 1, 15-089 Białystok, PolandDepartment of Clinical Immunology, Medical University of Białystok, Jana Kilińskiego 1, 15-089 Białystok, PolandDepartment of Clinical Immunology, Medical University of Białystok, Jana Kilińskiego 1, 15-089 Białystok, PolandSystemic vaccination with the BNT162b2 mRNA vaccine stimulates the humoral response. Our study aimed to compare the intensity of the humoral immune response, measured by SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing IgG antibody levels after COVID-19 vaccination versus after SARS-CoV-2 infection. We analyzed 1060 people in the following groups: convalescents; healthy unvaccinated individuals; individuals vaccinated with Comirnaty, AstraZeneca, Moderna, or Johnson & Johnson; and vaccinated SARS-CoV-2 convalescents. The concentrations of SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing antibodies were estimated in an oncology hospital laboratory by chemiluminescent immunoassay (CLIA; MAGLUMI). Results: (1) We observed a rise in antibody response in both the SARS-CoV-2 convalescent and COVID-19-vaccinated groups. (2) The levels of all antibody concentrations in vaccinated COVID-19 convalescents were significantly higher. (3) We differentiated asymptomatic SARS-CoV-2 convalescents from the control group. Our analysis suggests that monitoring SARS-CoV-2 IgG antibody concentrations is essential as an indicator of asymptomatic COVID-19 and as a measure of the effectiveness of the humoral response in convalescents and vaccinated people. Considering the time-limited effects of post-SARS-CoV-2 infection recovery or vaccination and the physiological half-life, among other factors, we suggest monitoring IgG antibody levels as a criterion for future vaccination.https://www.mdpi.com/2076-393X/10/2/334COVID-19BNT162b2vaccinationSARS-CoV-2reimmunization |
| spellingShingle | Piotr Kosiorek Dorota Elżbieta Kazberuk Anna Hryniewicz Robert Milewski Samuel Stróż Anna Stasiak-Barmuta Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed Vaccines COVID-19 BNT162b2 vaccination SARS-CoV-2 reimmunization |
| title | Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed |
| title_full | Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed |
| title_fullStr | Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed |
| title_full_unstemmed | Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed |
| title_short | Systemic COVID-19 Vaccination Enhances the Humoral Immune Response after SARS-CoV-2 Infection: A Population Study from a Hospital in Poland Criteria for COVID-19 Reimmunization Are Needed |
| title_sort | systemic covid 19 vaccination enhances the humoral immune response after sars cov 2 infection a population study from a hospital in poland criteria for covid 19 reimmunization are needed |
| topic | COVID-19 BNT162b2 vaccination SARS-CoV-2 reimmunization |
| url | https://www.mdpi.com/2076-393X/10/2/334 |
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