Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary
Background: COVID-19 may play a role in various immune-related dermatologic conditions. The relationship between COVID-19 and alopecia areata remains unclear. Objective: To review the existing literature for clinical studies and reports investigating the association between new-onset alopecia areata...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328722000177 |
| _version_ | 1811257422887518208 |
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| author | Rachel E. Christensen, BS Mohammad Jafferany, MD |
| author_facet | Rachel E. Christensen, BS Mohammad Jafferany, MD |
| author_sort | Rachel E. Christensen, BS |
| collection | DOAJ |
| description | Background: COVID-19 may play a role in various immune-related dermatologic conditions. The relationship between COVID-19 and alopecia areata remains unclear. Objective: To review the existing literature for clinical studies and reports investigating the association between new-onset alopecia areata or the exacerbation of preexisting alopecia areata following infection with SARS-CoV-2. Methods: A systematic review of the literature was performed using PubMed, Embase, and MEDLINE databases from inception to October 2021. Included articles assessed alopecia areata following infection with SARS-CoV-2. Results: Of 402 total articles, 9 were identified as meeting the inclusion criteria. Six articles described case reports of 7 patients with new-onset alopecia areata following confirmed infection with SARS-CoV-2, and 3 articles reported on alopecia areata recurrence or exacerbation following SARS-CoV-2 infection in patients with preexisting disease. Studies investigating the exacerbation or recurrence of alopecia areata following infection reported mixed findings. Limitations: A majority of the included studies were case reports. The heterogeneity of articles precluded data synthesis. Conclusion: Alopecia areata may be a dermatologic manifestation of COVID-19, with cases most often appearing 1 to 2 months following infection. Additional research is necessary to better elucidate the relationship and draw conclusions. |
| first_indexed | 2024-04-12T17:56:15Z |
| format | Article |
| id | doaj.art-1256246bd48b4d7da2d7402d32f712bb |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-04-12T17:56:15Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-1256246bd48b4d7da2d7402d32f712bb2022-12-22T03:22:19ZengElsevierJAAD International2666-32872022-06-0175761Association between alopecia areata and COVID-19: A systematic reviewCapsule SummaryRachel E. Christensen, BS0Mohammad Jafferany, MD1Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey; Correspondence to: Rachel E. Christensen, BS, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901.Department of Psychiatry and Behavioral Sciences, Central Michigan University College of Medicine, Mount Pleasant, MichiganBackground: COVID-19 may play a role in various immune-related dermatologic conditions. The relationship between COVID-19 and alopecia areata remains unclear. Objective: To review the existing literature for clinical studies and reports investigating the association between new-onset alopecia areata or the exacerbation of preexisting alopecia areata following infection with SARS-CoV-2. Methods: A systematic review of the literature was performed using PubMed, Embase, and MEDLINE databases from inception to October 2021. Included articles assessed alopecia areata following infection with SARS-CoV-2. Results: Of 402 total articles, 9 were identified as meeting the inclusion criteria. Six articles described case reports of 7 patients with new-onset alopecia areata following confirmed infection with SARS-CoV-2, and 3 articles reported on alopecia areata recurrence or exacerbation following SARS-CoV-2 infection in patients with preexisting disease. Studies investigating the exacerbation or recurrence of alopecia areata following infection reported mixed findings. Limitations: A majority of the included studies were case reports. The heterogeneity of articles precluded data synthesis. Conclusion: Alopecia areata may be a dermatologic manifestation of COVID-19, with cases most often appearing 1 to 2 months following infection. Additional research is necessary to better elucidate the relationship and draw conclusions.http://www.sciencedirect.com/science/article/pii/S2666328722000177AAalopecia areataCOVID-19inflammationSARS-CoV-2 |
| spellingShingle | Rachel E. Christensen, BS Mohammad Jafferany, MD Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary JAAD International AA alopecia areata COVID-19 inflammation SARS-CoV-2 |
| title | Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary |
| title_full | Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary |
| title_fullStr | Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary |
| title_full_unstemmed | Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary |
| title_short | Association between alopecia areata and COVID-19: A systematic reviewCapsule Summary |
| title_sort | association between alopecia areata and covid 19 a systematic reviewcapsule summary |
| topic | AA alopecia areata COVID-19 inflammation SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2666328722000177 |
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