Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review
Abstract Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the o...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-09-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | http://link.springer.com/article/10.1007/s13659-019-00220-5 |
| _version_ | 1818476872026030080 |
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| author | Rufin Marie Kouipou Toghueo |
| author_facet | Rufin Marie Kouipou Toghueo |
| author_sort | Rufin Marie Kouipou Toghueo |
| collection | DOAJ |
| description | Abstract Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders. Graphic Abstract |
| first_indexed | 2024-12-10T09:30:53Z |
| format | Article |
| id | doaj.art-125c40853a3c4e33ad63e4402202f10a |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-10T09:30:53Z |
| publishDate | 2019-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-125c40853a3c4e33ad63e4402202f10a2022-12-22T01:54:21ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092019-09-019531132810.1007/s13659-019-00220-5Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A ReviewRufin Marie Kouipou Toghueo0Antimicrobial and Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé IAbstract Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders. Graphic Abstracthttp://link.springer.com/article/10.1007/s13659-019-00220-5Anti-leishmanialAnti-inflammatoryEndophytesBioactive metabolites |
| spellingShingle | Rufin Marie Kouipou Toghueo Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review Natural Products and Bioprospecting Anti-leishmanial Anti-inflammatory Endophytes Bioactive metabolites |
| title | Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review |
| title_full | Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review |
| title_fullStr | Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review |
| title_full_unstemmed | Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review |
| title_short | Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review |
| title_sort | anti leishmanial and anti inflammatory agents from endophytes a review |
| topic | Anti-leishmanial Anti-inflammatory Endophytes Bioactive metabolites |
| url | http://link.springer.com/article/10.1007/s13659-019-00220-5 |
| work_keys_str_mv | AT rufinmariekouipoutoghueo antileishmanialandantiinflammatoryagentsfromendophytesareview |